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Journal of Neurorestoratology  2016, Vol. 4 Issue (1): 107-113    doi: 10.2147/JN.S119419
Review     
Progress of nerve bridges in the treatment of peripheral nerve disruptions
Qiang Ao
Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, Liaoning, Peoples’ Republic of China
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Abstract  Clinical repair of a nerve defect is one of the most challenging surgical problems. Autologous nerve grafting remains the gold standard treatment in addressing peripheral nerve injuries that cannot be bridged by direct epineural suturing. However, the autologous nerve graft is not readily available, and the process of harvesting autologous nerve graft results in several complications. Thus, it is necessary to explore an alternative to autologous nerve graft. In the last few decades, with significant advances in the life sciences and biotechnology, a lot of artificial nerve grafts have been developed to aim at the treatment of peripheral nerve disruptions. Artificial nerve grafts range from biological tubes to synthetic tubes and from nondegradable tubes to degradable tubes. Among them, acellular nerve allografts and artificial nerve repair conduits are two kinds of the most promising substitutes for nerve autografts. The history, research status, and prospect of acellular nerve allografts and artificial nerve repair conduits are described briefly in this review.

Key wordsperipheral nerve injury      repair      acellular nerve graft      nerve conduit     
Published: 26 December 2016
Corresponding Authors: Qiang Ao, Department of Tissue Engineering, School of Fundamental Sciences, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, Peoples’ Republic of China,Tel +86 135 2024 5337,Email aoqiang@tsinghua.edu.cn   
Cite this article:

Qiang Ao. Progress of nerve bridges in the treatment of peripheral nerve disruptions. Journal of Neurorestoratology, 2016, 4: 107-113.

URL:

http://jnr.tsinghuajournals.com/10.2147/JN.S119419     OR     http://jnr.tsinghuajournals.com/Y2016/V4/I1/107

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