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Journal of Neurorestoratology  2016, Vol. 4 Issue (1): 79-84    doi: 10.2147/JN.S119874
Review     
Mesenchymal stromal cell therapy in ischemic stroke
Ye Zhang, Hong Deng, Chao Pan, Yang Hu, Qian Wu, Na Liu, Zhouping Tang
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
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Abstract  Stroke is a clinical disease with high incidence, high disability rate, and high mortality. But effective and safe therapy for stroke remains limited. Adult mesenchymal stromal cells (MSCs) perform a variety of therapeutic functions. MSC delivery improves neurological outcomes in ischemic stroke models via neurorestorative and neuroprotective effects such as angiogenic effects, promoting endogenous proliferation, and reducing apoptosis and inflammation. MSC secretome also showed powerful therapeutic effects as a cell-based therapy in animal experiments. Several clinical trials on MSC implantation via different routes have now been completed in patients with stroke. Although challenges such as immunogenicity of allo-MSCs and large-scale production strategies need to be overcome, MSCs can be considered as a promising potential therapy for ischemic stroke.

Key wordsmesenchymal stromal cell      stroke      therapy      transplantation      exosomes     
Published: 26 December 2016
Corresponding Authors: Zhouping Tang, Department of Neurology, Tongji Hospital, to Tongji Medical College, Huazhong University of Science and Technology, Jiefang Blvd., No.1095, Wuhan 430030, People’s Republic of China,Tel +86 27 8366 3337,Fax +86 27 8366 2639,Email ddjtzp@163.com   
Cite this article:

Ye Zhang, Hong Deng, Chao Pan, Yang Hu, Qian Wu, Na Liu, Zhouping Tang. Mesenchymal stromal cell therapy in ischemic stroke. Journal of Neurorestoratology, 2016, 4: 79-84.

URL:

http://jnr.tsinghuajournals.com/10.2147/JN.S119874     OR     http://jnr.tsinghuajournals.com/Y2016/V4/I1/79

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