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Journal of Neurorestoratology  2017, Vol. 5 Issue (1): 47-50    doi: 10.2147/JN.S120173
Case Series     
Chromaffin cell transplantation for neuropathic pain after spinal cord injury: a report of two cases
Lin Chen1,2, Haitao Xi1, Juan Xiao1, Feng Zhang1, Di Chen1, Hongyun Huang1,3
1 Cell Therapy Center, Beijing Hongtianji Neuroscience Academy;
2 Department of Neurosurgery, Tsinghua University Yuquan Hospital;
3 Neurorestoratology Institute, General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China
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Abstract  Neuropathic pain (NP), a common secondary complication following spinal cord injury (SCI), presenting at or below the level of injury is largely refractory to current pharmacological, physical, and surgical treatments. Previous studies have demonstrated the promising value of cell therapy including adrenal chromaffin cells that have the capacity to act as mini-pumps that release amines and peptides for alleviating chronic pain. The paper presents the cases of two gentlemen suffering from severe central NP after thoracic SCI. Six months after chromaffin cell intrathecal injection, their pain relieved significantly. The results demonstrated the preliminary therapeutic efficacy of chromaffin cell transplants in people with NP, and support further research of this treatment strategy for the management of intractable chronic pain due to SCI.

Key wordschromaffin cell      cell transplantation      neuropathic pain      spinal cord injury     
Received: 19 August 2016      Published: 26 December 2017
Corresponding Authors: Hongyun Huang, Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, Lingxiu Building, No.1 Gucheng Street, Beijing 100143, People’s Republic of China Tel +86 139 1011 6608 Email   
Cite this article:

Lin Chen, Haitao Xi, Juan Xiao, Feng Zhang, Di Chen, Hongyun Huang. Chromaffin cell transplantation for neuropathic pain after spinal cord injury: a report of two cases. Journal of Neurorestoratology, 2017, 5: 47-50.

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