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Journal of Neurorestoratology  2017, Vol. 5 Issue (1): 1-4    doi: 10.2147/JN.S120524
Case Report     
Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury
Feng Zhang1,2, Xiangzhi Meng2, Fang Lu2, Aixian Liu2, Hongyun Huang1,2
1 Cell Therapy Center, Beijing Hongtianji Neuroscience Academy;
2 Neurorehabilitation Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, People’s Republic of China
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Abstract  Objective: To observe the result of olfactory ensheathing cell (OEC) transplantation in a patient with chronic sciatic nerve injury. Case report: A 53-year-old male patient with chronic (1 year) sciatic nerve injury on left side received OEC transplantation at the lesion site. He received follow-up assessment according to the American Spinal Injury Association standard at 10 days, 6 months, and 1 year after OEC therapy. The muscle strength of his left lower limb increased and numbness decreased during the early stage of cell therapy. His motor function improved with each evaluation. His limp walking gait recovered, and numbness sensation got nearly normal after 1 year of follow-up. There were no side effects. Conclusion: OEC transplantation may be an option for chronic peripheral (sciatic) nerve injury.

Key wordsolfactory ensheathing cell transplantation      sciatic nerve injury      peripheral nerve injury      function improvement      neurorestoration     
Received: 24 August 2016      Published: 26 December 2017
Corresponding Authors: Hongyun Huang, Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, No. 1 Gucheng Street, Shijingshan District, Beijing, People’s Republic of China Tel +86 139 1011 6608 Email   
Cite this article:

Feng Zhang, Xiangzhi Meng, Fang Lu, Aixian Liu, Hongyun Huang. Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury. Journal of Neurorestoratology, 2017, 5: 1-4.

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