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Journal of Neurorestoratology  2018, Vol. 6 Issue (1): 115-119    doi: 10.2147/JN.S147917
METHODOLOGY     
Neurorestorative clinical application standards for the culture and quality control of neural progenitor/precursor cells (version 2017)
Shiqing Feng1, Juan Xiao2,3, Fabin Han4, Lin Chen5, Wenyong Gao2,3, Gengsheng Mao2, Hongyun Huang2,3,(✉)
1?International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, China
2?Institute of Neurorestoratology, The General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China
3 Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, Beijing 100043, China
4?The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/Liaocheng People’s Hospital, Liaocheng 252000, China
5?Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China
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Abstract  

In order to promote the clinical use of neural progenitor or precursor cells for treating neurological diseases and damage, we need to standardize culture procedures for these cells. The Chinese Association of Neurorestoratology put forward these standards for training operators, standardized use and management of materials and equipment, standardized isolation and culture for neural progenitor/precursor cells, and the standardized management in preservation, transport, and related safe operation procedures of the neural progenitors. These cultures and quality control standards also include the Good Manufacturing Practice environment, routine maintenance as well as the monitoring and reporting of the clinical-grade neural progenitor cells. The aim of these standards is to improve the therapeutic efficacy and minimize the possible side effects from lake of quality control.



Key wordsstandardization      cell culture      quality control      neural progenitor cells      neural precursor cells      neurorestoratology     
Received: 01 August 2017      Published: 09 November 2018
Corresponding Authors: Hongyun Huang   
About author: §These authors contributed equally to this work
Cite this article:

Shiqing Feng, Juan Xiao, Fabin Han, Lin Chen, Wenyong Gao, Gengsheng Mao, Hongyun Huang. Neurorestorative clinical application standards for the culture and quality control of neural progenitor/precursor cells (version 2017). Journal of Neurorestoratology, 2018, 6: 115-119.

URL:

http://jnr.tsinghuajournals.com/10.2147/JN.S147917     OR     http://jnr.tsinghuajournals.com/Y2018/V6/I1/115

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