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Journal of Neurorestoratology  2015, Vol. 3 Issue (1): 123-132    doi: 10.2147/JN.S70337
Review     
Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review
Munyaradzi Kamudzandu, Paul Roach, Rosemary A Fricker, Ying Yang
Institute for Science and Technology in Medicine, School of Medicine, Keele University, Stoke-on-Trent, UK
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Abstract  Restoration of function following damage to the central nervous system (CNS) is severely restricted by several factors. These include the hindrance of axonal regeneration imposed by glial scars resulting from inflammatory response to damage, and limited axonal outgrowth toward target tissue. Strategies for promoting CNS functional regeneration include the use of nanotechnology. Due to their structural similarity, synthetic nanofibers could play an important role in regeneration of CNS neural tissue toward restoration of function following injury. Two-dimensional nanofibrous scaffolds have been used to provide contact guidance for developing brain and spinal cord neurites, particularly from neurons cultured in vitro. Three-dimensional nanofibrous scaffolds have been used, both in vitro and in vivo, for creating cell adhesion permissive milieu, in addition to contact guidance or structural bridges for axons, to control reconnection in brain and spinal cord injury models. It is postulated that nanofibrous scaffolds made from biodegradable and biocompatible materials can become powerful structural bridges for both guiding the outgrowth of neurites and rebuilding glial circuitry over the “lesion gaps” resulting from injury in the CNS.

Key wordsscaffold      nanofibrous scaffold      CNS      regeneration      alignment     
Published: 26 December 2015
Corresponding Authors: Ying Yang, Institute for Science and Technology in Medicine, School of Medicine, Keele University, Thornburrow Drive, Stoke-on-Trent ST4 7QB, Staffordshire, UK, Tel +44 1782 674 386, Fax +44 1782 674 467, Email y.yang@keele.ac.uk   
Cite this article:

Munyaradzi Kamudzandu, Paul Roach, Rosemary A Fricker, Ying Yang. Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, 2015, 3: 123-132.

URL:

http://jnr.tsinghuajournals.com/10.2147/JN.S70337     OR     http://jnr.tsinghuajournals.com/Y2015/V3/I1/123

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