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Journal of Neurorestoratology  2015, Vol. 3 Issue (1): 57-62    doi: 10.2147/JN.S74486
Review     
Clinical neurorestorative progress in traumatic brain injury
Huiling Huang1, Lin Chen2,3, Hongyun Huang4-6
1Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin Neurosurgical Institute, Tianjin, People's Republic of China;
2Medical Center, Tsinghua University, Beijing, People's Republic of China;
3Tsinghua University Yuquan Hospital, Beijing, People's Republic of China;
4General Hospital of Chinese people's Armed Police Forces,
5Beijing Rehabilitation Hospital of Capital Medical University, Beijing, People's Republic of China;
6Beijing Hongtianji Neuroscience Academy, Beijing, People's Republic of China;
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Abstract  Traumatic brain injury (TBI) is a leading cause of death and disability from trauma to the central nervous system. Besides the surgical interventions and symptomatic management, the conventional therapies for TBI and its sequelae are still limited. Recently emerging evidence suggests that some neurorestorative treatments appear to have a potential therapeutic role for TBI and improving the patient's quality of life. The current clinical neurorestorative strategies available in TBI include pharmacological treatments (recombinant human interleukin-1 receptor antagonist, amantadine, lithium, and valproate), the neuromodulation treatments (repetitive transcranial magnetic stimulation, transcranial direct current stimulation, and low-level laser therapy), cell transplantation (bone marrow stromal cells and umbilical cord stromal cells), and combined neurorehabilitation. In this review, we summarize the recent clinical neurorestorative progress in the management of neurodegeneration as well as cognitive and motor deficits after TBI; indeed further clinical trials are required to provide more robust evidence.

Key wordsbrain trauma      neurorestorative treatment      cell transplantation      clinical study     
Published: 26 December 2015
Corresponding Authors: Huiling Huang, No 122 Qixiangtai Road, Hexi District, Tianjin, 300060, People's Republic of China Email huanghuiling@126.com;Lin Chen, No 5 Shijingshan Road, Shijingshan District, Beijing 100040, People's Republic of China, Email chenlin_china@163.com   
Cite this article:

Huiling Huang, Lin Chen, Hongyun Huang. Clinical neurorestorative progress in traumatic brain injury. Journal of Neurorestoratology, 2015, 3: 57-62.

URL:

http://jnr.tsinghuajournals.com/10.2147/JN.S74486     OR     http://jnr.tsinghuajournals.com/Y2015/V3/I1/57

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