Please wait a minute...
Journal of Neurorestoratology  2016, Vol. 4 Issue (1): 45-50    doi: 10.2147/JN.S98584
Case Report     
Cell-based neurorestorative therapy for postpoliomyelitis syndrome: a case report
Haitao Xi1,2,*, Di Chen1,*
1Center of Neurorestoratology, Beijing Hongtianji Neuroscience Academy;
2Center of Neurorestoratology, Beijing Rehabilitation Hospital affiliated Capital Medical University, Beijing, People’s Republic of China
Download: PDF (2602 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Postpoliomyelitis syndrome refers to the new neuromuscular symptoms that occur in patients, years after their acute poliomyelitis has stabilized. A 64-year-old Danish man presented with lower limb weakness and severe pain for 2 years and 5 months. He had a history of poliomyelitis affecting his limbs 59 years ago. Physical examination revealed atrophy of muscles of both lower limbs. Electromyography revealed that recruitment of maximal voluntary contraction of muscles was decreased in the affected muscles. He received cell-based neurorestorative therapy during admission, and then, his neurological function improved and remained stable during 4-year follow-up. This case report shows that cell therapy could be a treatment option for postpoliomyelitis syndrome.

Key wordspostpoliomyelitis syndrome      neuromuscular disease      cell transplantation      cell-based neurorestorative therapy     
Published: 26 December 2016
Corresponding Authors: Haitao Xi,Beijing Hongtianji Neuroscience Academy, Lingxiu Building, No 1 at Gucheng, Shijingshan District, Beijing 100143, People’s Republic of China,Tel +86 10 138 1169 5976,Email   
Cite this article:

Haitao Xi, Di Chen. Cell-based neurorestorative therapy for postpoliomyelitis syndrome: a case report. Journal of Neurorestoratology, 2016, 4: 45-50.

URL:     OR

1. Willén C, Thorén-Jönsson, AL, Grimby G, Sunnerhagen, KS.Disability in a 4-year follow-up study of people with post-polio syndrome.J Rehabil Med. 2007;39(2):175-180.
2. Corrêa JC, Rocco CC, de Andrade DV, Peres JA, Corrêa FI. Electromyographic and neuromuscular analysis in patients with post-polio syndrome.Electromyogr Clin Neurophysiol. 2008;48(8):329-333.
3. Trojan DA, Cashman NR.Post-poliomyelitis syndrome.Muscle Nerve. 2005;31(1):6-19.
4. Gonzalez H, Sunnerhagen KS, Sjöberg I, Kaponides G, Olsson T, Borg K.Intravenous immunoglobulin for post-polio syndrome: a randomised controlled trial.Lancet Neurol. 2006;5(6):493-500.
5. Oncu J, Durmaz B, Karapolat H.Short-term effects of aerobic exercise on functional capacity, fatigue, and quality of life in patients with post-polio syndrome.Clin Rehabil. 2009;23(2):155-163.
6. Kalkman JS, Schillings ML, Zwarts MJ, van Engelen BG, Bleijenberg G. The development of a model of fatigue in neuromuscular disorders: a longitudinal study.J Psychosom Res. 2007;62(5):571-579.
7. Boyer FC, Tiffreau V, Rapin A, Laffont I, Percebois-Macadré L, Supper C, Novella JL, Yelnik AP.Post-polio syndrome: Pathophysiological hypotheses, diagnosis criteria, medication therapeutics.Ann Phys Rehabil Med. 2010;53(1):34-41.
8. Chen L, Huang HY. [Neurorestoratology: new concept and bridge from bench to bedside].Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009;23(3):366-370.
9. International Association of Neurorestoratology. Beijing declaration of international association of neurorestoratology (IANR).Cell Transplant. 2009;18(4):487.
10. Liu K, Li Y, Wang H, et al.The immunohistochemical characterization of human fetal olfactory bulb and olfactory ensheathing cells in culture as a source for clinical CNS restoration.Anat Rec (Hoboken). 2010;293(3):359-369.
11. Huang H.Neurorestoratology, a distinct discipline and a new era: a brief introduction to the first IANR section.Cell Transplant. 2010;19(2):129-131.
12. Huang H, Chen L, Sanberg P.Cell therapy from bench to bedside translation in CNS neurorestoratology era.Cell Med. 2010;1(1):15-46.
13. Sanberg PR, Eve DJ, Willing AE, et al.The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells.Cell Transplant. 2011;20(1):85-94.
14. Huang HY, Chen L, Xi H, et al.Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study.Clin Transplant. 2008;22(6):710-718.
15. Huang HY, Xi HT, Chen L, Zhang F, Liu YC.Long-term outcome of olfactory ensheathing cell therapy for patients with complete chronic spinal cord injury.Clin Transplant. 2012;21(S1):S23-31.
16. Tetzlaff W, Okon EB, Karimi-Abdolrezaee S, et al.A systematic review of cellular transplantation therapies for spinal cord injury.J Neurotrauma. 2011;28(8):1611-1682.
17. Chen L, Huang HY, Xi HT, et al.Intracranial transplant of olfactory ensheathing cells in children and adolescents with cerebral palsy: a randomized controlled clinical trial.Cell Transplant. 2010;19(2):185-191.
18. Chen L, Chen D, Xi HT, et al.Olfactory ensheathing cell neurorestorotherapy for amyotrophic lateral sclerosis patients: benefits from multiple transplantations.Cell Transplantat. 2012;21(Supp 1):S65-77.
19. Bohbot A.Olfactory ensheathing glia transplantation combined with laserponcture® in human spinal cord injury: results measured by electromyography monitoring.Cell Transplant. 2010;19:179-184.
20. People’s Republic of China, Ministry of Public Health, Science and Technology Bureau, 1991. Instruction for prepare and clinical application of the aborted human fetuses (91-006).
21. Xi HT, Chen L, Huang HY, et al.Preliminary report of multiple cell therapy for patients with multiple system atrophy.Cell Transplant. 2013;22(Suppl 1):S93-S99.
22. Chen L, Xi HT, Huang H, et al.Multiple cell transplantation based on an intraparenchymal approach for patients with chronic phase stroke.Cell Transplant. 2013;22(Suppl 1):S83-S91.
23. Ditunno JF Jr.American spinal injury standards for neurological and functional classification of spinal cord injury: past, present and future. 1992 Heiner Sell lecture of the American Spinal Injury Association.J Am Paraplegia Soc. 1994;17(1):7-11.
24. International Association of Neurorestoratology. Clinical application of the principle of cell transplantation in neurorestoratology. Chinese J Reparat Reconstruct Surg. 2008;22(8):1021-1023. Available from:. Clinical application of the principle of cell transplantation in neurorestoratology. Chinese J Reparat Reconstruct Surg. 2008;22(8):1021-1023. Available from:
25. Okano H.Neural stem cells and strategies for the regeneration of the central nervous system.Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(4):438-450.
26. Orlacchio A, Bernardi G, Orlacchio A, Martino S.Stem cells: an overview of the current status of therapies for central and peripheral nervous system diseases.Curr Med Chem. 2010;17(7):595-608.
27. Huang HY, Chen L, Xi HT, et al. [Olfactory ensheathing cells transplantation for central nervous system diseases in 1,255 patients].Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009;23(1):14-20.
28. Pastuszak Ż, Tomczykiewicz K, Stępień A.Post-polio syndrome - a case report.Pol Merkur Lekarski. 2015;39(229):37-39.
29. Wang F, Yasuhara T, Shingo T, et al.Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1 alpha.BMC Neurosci. 2010;11(1):52.
30. Blits B, Boer GJ, Verhaagen J.Pharmacological cell and gene therapy strategies to promote spinal cord regeneration.Cell Transplant. 2002;11(6):593-613.
31. Ramon-Cueto A, Valverde F.Olfactory bulb ensheathing glia: a unique cell type with axonal growth-promoting properties.Glia. 1995;14(3):163-173.
32. Meng J, Adkin CF, Arechavala-Gomeza V, Boldrin L, Muntoni F, Morgan JE.The contribution of human synovial stem cells to skeletal muscle regeneration.Neuromuscul Disord. 2010;20(1):6-15.
33. Yohn DC, Miles GB, Rafuse VF, Brownstone RM. Transplanted mouse embryonic stem-cell-derived motoneurons form functional motor units and reduce muscle atrophy. J Neurosci.2008;19;28(47):12409-12418.
[1] Chao Chen, Qingfa Chen, Yan Liu, Chongyang Zhang, Kaixiang Zhu, Xue Li, Haitao Xie, Rui Zhang. The cell repair research for Parkinson’s disease: A systematic review[J]. Journal of Neurorestoratology, 2020, 8(2): 93-103.
[2] Zhenrong Zhang, Fangyong Wang, Mingjie Song. The cell repair research of spinal cord injury: a review of cell transplantation to treat spinal cord injury[J]. Journal of Neurorestoratology, 2019, 7(2): 55-62.
[3] Zhongju Shi, Zhijian Wei, Shiqing Feng, Gustavo Moviglia, Lin Chen, Ping Wu. Highlights for the 10th Annual Conference of the International Association of Neurorestoratology[J]. Journal of Neurorestoratology, 2018, 6(1): 84-87.
[4] Andrey S. Bryukhovetskiy. Translational experience of 28 years of use of the technologies of regenerative medicine to treat complex consequences of the brain and spinal cord trauma: Results, problems and conclusions[J]. Journal of Neurorestoratology, 2018, 6(1): 99-114.
[5] Lin Chen, Yuqi Zhang, Xijing He, Saberi Hooshang. Comparison of intramedullary transplantation of olfactory ensheathing cell for patients with chronic complete spinal cord injury worldwide[J]. Journal of Neurorestoratology, 2018, 6(1): 146-151.
[6] Feng Zhang, Xiangzhi Meng, Fang Lu, Aixian Liu, Hongyun Huang. Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury[J]. Journal of Neurorestoratology, 2017, 5(1): 1-4.
[7] Lin Chen, Haitao Xi, Juan Xiao, Feng Zhang, Di Chen, Hongyun Huang. Chromaffin cell transplantation for neuropathic pain after spinal cord injury: a report of two cases[J]. Journal of Neurorestoratology, 2017, 5(1): 47-50.
[8] Weston Miller. Stem cell-transplantation therapy for adrenoleukodystrophy: current perspectives[J]. Journal of Neurorestoratology, 2017, 5(1): 5-19.
[9] Mitsuhiro Enomoto. Therapeutic effects of neurotrophic factors in experimental spinal cord injury models[J]. Journal of Neurorestoratology, 2016, 4(1): 15-22.
[10] Lin Chen, Hongyun Huang, Wei-Ming Duan, Gengsheng Mao. Clinical neurorestorative progress in Parkinson's disease[J]. Journal of Neurorestoratology, 2015, 3(1): 101-108.
[11] Lin Chen, Hongyun Huang, Haitao Xi, Gengsheng Mao. Clinical neurorestorative progress in amyotrophic lateral sclerosis[J]. Journal of Neurorestoratology, 2015, 3(1): 109-114.
[12] Huiling Huang, Lin Chen, Hongyun Huang. Clinical neurorestorative progress in traumatic brain injury[J]. Journal of Neurorestoratology, 2015, 3(1): 57-62.
[13] Hooshang Saberi, Nazi Derakhshanrad, Mir Saeed Yekaninejad. Review of recently documented clinical neuroprotective and cellular treatment for spinal cord injury: an analysis of outcomes[J]. Journal of Neurorestoratology, 2014, 2(1): 15-24.
[14] John R Bach, Anokhi D Mehta. Respiratory muscle aids to avert respiratory failure and tracheostomy: a new patient management paradigm[J]. Journal of Neurorestoratology, 2014, 2(1): 25-36.
[15] Zhicheng Zhang, Fang Li, Tiansheng Sun, Dajiang Ren, Xiumei Liu. Therapeutic effects of NogoA vaccine and olfactory ensheathing glial cell implantation on acute spinal cord injury[J]. Journal of Neurorestoratology, 2013, 1(1): 43-53.