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Journal of Neurorestoratology  2017, Vol. 5 Issue (1): 51-57    doi: 10.2147/JN.S99014
Review     
Clinical neurorestorative progresses in cerebral palsy
Alok Sharma1, Tongchao Geng2, Hemangi Sane3, Pooja Kulkarni3
1 Department of Medical Services & Clinical Research, NeuroGen Brain and Spine Institute, Mumbai, India;
2 Department of Neurology, Yuquan Hospital, Tsinghua University, Beijing, People’s Republic of China;
3 Department of Research and Development, Neurogen Brain and Spine Institute, Mumbai, India
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Abstract  Cerebral palsy (CP), group of permanent nonprogressive clinical disorders in children, is caused by damage to the immature brain. Conventionally available treatments for CP are mainly targeted toward management of its symptoms. With the upcoming field of neurorestorative strategies, we are now able to repair the core brain damage in CP. There are various drugs, stem cells, etc, which have been implicated to have neurorestorative properties. Autologous bone marrow stem cells, umbilical cord stem cells, neural stem cells, and olfactory ensheathing cells have shown the safety and efficacy in preliminary studies. Here, we review the different medicines and cell types that have shown beneficial effects in clinical studies. We propose that combination strategies may be the future of neurorestoration.

Key wordsstem cell therapy      bone marrow      umbilical cord      neural cells      regenerative medicine      brain     
Received: 23 October 2015      Published: 26 December 2017
Corresponding Authors: Alok Sharma, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre Plot No 19, Sector 40, Opp Rail Vihar, Next to Seawood Station (W), Navi Mumbai-400706, India Tel +91 22 2528 3706 Email alok276@gmail.com   
Cite this article:

Alok Sharma, Tongchao Geng, Hemangi Sane, Pooja Kulkarni. Clinical neurorestorative progresses in cerebral palsy. Journal of Neurorestoratology, 2017, 5: 51-57.

URL:

http://jnr.tsinghuajournals.com/10.2147/JN.S99014     OR     http://jnr.tsinghuajournals.com/Y2017/V5/I1/51

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