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Journal of Neurorestoratology  2018, Vol. 6 Issue (1): 88-92    doi: 10.26599/JNR.2018.9040007
Review Article     
Optogenetics to restore neural circuit function in Parkinson’s disease
Hyung Ho Yoon, Joongkee Min, Sang Ryong Jeon(✉)
Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
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Abstract  

Deep brain stimulation surgery has been performed in various movement disorders and psychiatric diseases. However, electrical stimulation may unexpectedly affect other types of adjacent neurons outside of the target area. Recently, optogenetics has provided the opportunity to modulate specific target neurons. Since this novel technique can individually control specific neurons in freely moving animals, it could be proposed to restore neural circuit function to related diseases, such as affective disorders, Huntington’s disease (HD), and Parkinson’s disease (PD). Herein, we discuss how optogenetics works as a treatment for Parkinson’s disease and other neural circuit dysfunctions.



Key wordsdeep brain stimulation      optogenetics      neural circuit      Parkinson disease     
Received: 09 July 2018      Published: 09 November 2018
Corresponding Authors: Sang Ryong Jeon   
About author: §These authors contributed equally to this work.
Cite this article:

Hyung Ho Yoon, Joongkee Min, Sang Ryong Jeon. Optogenetics to restore neural circuit function in Parkinson’s disease. Journal of Neurorestoratology, 2018, 6: 88-92.

URL:

http://jnr.tsinghuajournals.com/10.26599/JNR.2018.9040007     OR     http://jnr.tsinghuajournals.com/Y2018/V6/I1/88

Fig.?1A use of Cre transgenic mouse for targeting. A combination of specific cell type Cre mice and stereotactic viral injection can induce optogene expression in specific cell type.
Fig.?2Behavioral tests. (a) Stepping test is a method to evaluate motor function of forelimbs. (b) Cylinder test can indicate the preference of either forelimb. (c) Drug induced rotation test can assess the degree of asymmetrical dopaminergic release.
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