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Journal of Neurorestoratology  2018, Vol. 6 Issue (1): 171-178    doi: 10.26599/JNR.2018.9040013
Review Article     
Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses
Hongyun Huang1,2,(✉), Hari Shanker Sharma3, Lin Chen4, Ali Otom5, Ziad M. Al Zoubi6, Hooshang Saberi7, Dafin F. Muresanu8, Xijing He9
1 Institute of Neurorestoratology, Third Medical Center of PLA General Hospital, Beijing, China
2 Hongtianji Neuroscience Academy, Lingxiu building, Beijing, China
3 Intensive Experimental CNS Injury and Repair, University Hospital, UppsalaUniversity, Uppsala, Sweden
4 Department of Neurorestoratology, Tsinghua University Yuquan Hospital, Beijing, China
5 Royal Specialty Center for Spine and Musculoskeletal Disorders Amman, Jordan
6 Jordan Ortho and Spinal Centre, Al-Saif Medical Center, Amman, Jordan
7 Department of Neurosurgery, Brain and Spinal cord Injury Research center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
8 Department of Neurosciences “Iuliu Hatieganu,” University of Medicine and Pharmacy, Cluj-Napoca, Romania
9 Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
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Abstract  

Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies. In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords “neurorestorative strategies”, “spinal cord injury”, “cell therapy”, “neuromodulation”, and “nerve bridges”. Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.



Key wordsneurorestorative strategies      spinal cord injury      cell therapy      neuromodulation      nerve bridges     
Received: 01 December 2018      Published: 30 December 2018
Corresponding Authors: Hongyun Huang   
Cite this article:

Hongyun Huang, Hari Shanker Sharma, Lin Chen, Ali Otom, Ziad M. Al Zoubi, Hooshang Saberi, Dafin F. Muresanu, Xijing He. Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses. Journal of Neurorestoratology, 2018, 6: 171-178.

URL:

http://jnr.tsinghuajournals.com/10.26599/JNR.2018.9040013     OR     http://jnr.tsinghuajournals.com/Y2018/V6/I1/171

[1]   Huang H, Chen L. Commentary: Neurorestoratology: A concept and emerging discipline in the treatment of neurological disorders. CNS Neurol Disord Drug Targets. 2016, 15(5): 522-525.
[2]   Huang H, Sun T, Chen L, et al. Consensus of clinical neurorestorative progresses in patients with complete chronic spinal cord injury. Cell Transplant. 2014, 23: S1-13.
[3]   Huang H, Mao G, Feng S, et al. 2016 yearbook of neurorestoratology. J. Neurorestoratology 2017, 5: 111-115.
[4]   Huang H, Skaper S, Mao G, et al. 2017 yearbook of neurorestoratology. J. Neurorestoratology 2018, 6: 67-70
[5]   Anderberg L, Aldskogius H, Holtz A. Spinal cord injury– Scientific challenges for the unknown future. Ups. J. Med. Sci. 2007, 112: 259-288.
[6]   Huang, H. Neurorestoratology, a distinct discipline and a new era: A brief introduction to the first IANR section. Cell Transplant. 2010, 19: 129-131.
[7]   Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the second national acute spinal cord injury study. N Engl J Med 1990, 322(20): 1405-1411.
[8]   Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazadmesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third national acute spinal cord injury randomized controlled trial. National acute spinal cord injury study. JAMA 1997, 277(20): 1597-1604.
[9]   Bracken MB, Shepard MJ, Holford TR, et al. Methylprednisolone or tirilazadmesylate administration after acute spinal cord injury: 1-year follow up. Results of the third national acute spinal cord injury randomized controlled trial. J Neurosurg 1998, 89(5): 699-706.
[10]   Bauchet LN, Lonjon FE, Perrin C, et al. Strategies for spinal cord repair after injury: A review of the literature and information. Annals of Physical and Rehabilitation Medicine 2009, 52: 330-351.
[11]   Bracken MB. Steroids for acute spinal cord injury. Cochrane Database Syst Rev 2012, 6: CD001046.
[12]   Hurlbert RJ, Hadley MN, Walters BC, et al. Pharmacological therapy for acute spinal cord injury. Neurosurgery 2013, 72(): 93-105.
[13]   Walters BC, Hadley MN, Hurlbert RJ, et al; American Association of Neurological Surgeons; Congress of Neurological Surgeons. Guidelines for the management of acute cervical spine and spinal cord injuries: 2013 update. Neurosurgery. 2013, 60(): 82-91.
[14]   Evaniew N, Noonan VK, Fallah N, et al. Methylprednisolone for the treatment of patients with acute spinal cord injuries: A propensity score-matched cohort study from a canadian multi-center spinal cord injury registry. J Neurotrauma 2015, 32(21): 1674-1683.
[15]   Hurlbert RJ, Hadley MN, Walters BC, et al. Pharmacological therapy for acute spinal cord injury. Neurosurgery 2015, 76(): S71-83.
[16]   Geisler FH, Dorsey FC, Coleman WP. Recovery of motor function after spinal-cord injury—A randomized, placebo- controlled trial with GM-1 ganglioside. N Engl J Med. 1991, 324(26): 1829-1838.
[17]   Geisler F H, Coleman W P, Grieco G, et al. The Sygen multicenter acute spinal cord injury study. Spine 2001, 26(24 ): S87-98.
[18]   Chinnock P, Roberts I. Gangliosides for acute spinal cord injury. Cochrane Database Syst Rev 2005, 2: CD004444.
[19]   Resnick DK. Updated guidelines for the management of acute cervical spine and spinal cord injury. Neurosurgery 2013, 72(): 1.
[20]   Filho BTEP, De AFF, Paz HLD, et al. The effect of monosialoganglyoside (GM-1) administration in spinal cord injury. Acta Ortopedica Brasileira 2016, 24(3): 123-126.
[21]   Bracken MB, Shepard MJ, Holford TR, et al. Methylprednisolone or tirilazadmesylate administration after acute spinal cord injury: 1-year follow up. Results of the third national acute spinal cord injury randomized controlled trial. J Neurosurg. 1998, 89(5): 699-706.
[22]   Alibai EA, Baghban F, Farrokhi MR, et al. Effects of human erythropoietin on functional outcome of patients with traumatic cervical cord injury; a pilot randomized clinical trial. Bull Emerg Trauma. 2015, 3(3): 79-85.
[23]   Casha S, Zygun D, McGowan MD, et al. Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. Brain. 2012, 135(Pt 4): 1224-1236.
[24]   Wu JC, Huang WC, Tsai YA, et al. Nerve repair using acidic fibroblast growth factor in human cervical spinal cord injury: A preliminary Phase I clinical study. J Neurosurg Spine. 2008, 8(3): 208-214.
[25]   Derakhshanrad N, Saberi H, Yekaninejad MS, et al. Granulocyte-colony stimulating factor administration for neurological improvement in patients with postrehabilitation chronic incomplete traumatic spinal cord injuries: a double- blind randomized controlled clinical trial. J Neurosurg Spine. 2018, 29(1): 97-107.
[26]   Galanda M, Nádvorník P, Fr?hlich J. Surgical treatment of spasticity in spinal cord injuries (critical comments on longitudinal myelotomy). Bratisl Lek Listy. 1974, 61(5): 589-594.
[27]   Yamada S, Perot PL Jr, Ducker TB, et al. Myelotomy for control of mass spasms in paraplegia. J Neurosurg. 1976, 45(6): 683-691.
[28]   Borovich B, Peyser E, Gruskiewicz J. Acute central and intermediate cervical cord injury. Neurochirurgia (Stuttg). 1978, 21(3): 77-84.
[29]   Wu G, Zhao L. Field Surgery. Shanghai Scientific and Technologic Press, 1981.
[30]   Tachibana S, Okada K, Ohwada T, et al. Posterior longitudinal myelotomy as a surgical treatment of acute cervical spinal cord injury. No Shinkei Geka. 1984, 12(2): 183-188.
[31]   Koyanagi I, Iwasaki Y, Isu T, et al. Myelotomy for acute cervical cord injury. Report of four cases. Neurol Med Chir (Tokyo). 1989, 29(4): 302-306.
[32]   Carlsson CA, Sundin T. Reconstruction of efferent pathways to the urinary bladder in a paraplegic child. Rev Surg. 1967, 24(1): 73-76.
[33]   Zhang S, Johnston L, Zhang Z, et al. Restoration of stepping- forward and ambulatory function in patients with paraplegia: rerouting of vascularized intercostal nerves to lumbar nerve roots using selected interfascicular anastomosis. Surg Technol Int. 2003, 11: 244-248.
[34]   von Wild KR, Brunelli GA. Restoration of locomotion in paraplegics with aid of autologous bypass grafts for direct neurotisation of muscles by upper motor neurons—the future: Surgery of the spinal cord? Acta Neurochir Suppl. 2003, 87: 107-112.
[35]   Livshits A, Catz A, FolmanY, et al. Reinnervation of the neurogenic bladder in the late period of the spinal cord trauma. Spinal Cord. 2004, 42(4): 211-217.
[36]   Xiao CG, Du MX, Dai C, et al. An artificial somatic-central nervous system-autonomic reflex pathway for controllable micturition after spinal cord injury: Preliminary results in 15 patients. J Urol. 2003, 170(4 Pt 1): 1237-1241.
[37]   Iumashev GS, Aganesov AG. Reconstructive surgery in complicated trauma of the thoracic and lumbar segments of the spine. Vestn Khir Im I IGrek. 1989, 143(11): 61-64.
[38]   He Z, ZhangY, Song L, et al. preliminary report of fetal brain transplantation into spinal cord for traumatic paraplegia. Shanghai Medicine. 1995, 18: 650-652.
[39]   Falci S, Holtz A, Akesson E, et al. Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: first clinical attempt. J Neurotrauma. 1997, 14(11): 875-884.
[40]   Huang H, Chen L, Wang H, et al. Influence of patients’ age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury. Chin Med J (Engl). 2003, 116(10): 1488-1491.
[41]   Rabinovich SS, Seledtsov VI, Poveschenko OV, et al. Transplantation treatment of spinal cord injury patients. Biomed Pharmacother. 2003, 57(9): 428-433.
[42]   Kang KS, Kim SW, Oh YH, et al. A 37-year-old spinal cord- injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy. 2005, 7(4): 368-373.
[43]   Chernykh ER, Stupak VV, Muradov GM, et al. Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients. Bull ExpBiol Med. 2007, 143(4): 543-547.
[44]   Deda H, Inci MC, Kürek?i AE, et al. Treatment of chronic spinal cord injured patients with autologous bone marrow- derived hematopoietic stem cell transplantation: 1-year follow-up. Cytotherapy. 2008, 10(6): 565-574.
[45]   Kumar AA, Kumar SR, Narayanan R, et al. Autologous bone marrow derived mononuclear cell therapy for spinal cord injury: A phase I/II clinical safety and primary efficacy data. Exp Clin Transplant. 2009, 7(4): 241-248.
[46]   Moviglia GA, Fernandez Vi?a R, Brizuela JA, et al. Combined protocol of cell therapy for chronic spinal cord injury (by IV and IA). Report on the electrical and functional recovery of two patients. Cytotherapy. 2006, 8(3): 202-209.
[47]   Huang H, Xi H, Chen L, et al. Long-term outcome of olfactory ensheathing cell therapy for patients with complete chronic spinal cord injury. Cell Transplant 2012, 21: S23-S31
[48]   von Wild K, Rabischong P, Brunelli G, et al. Computer added locomotion by implanted electrical stimulation in paraplegic patients (SUAW). Acta Neurochir Suppl. 2002, 79: 99-104.
[49]   Minassian K, Jilge B, Rattay F, et al. Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: electromyographic study of compound muscle action potentials. Spinal Cord. 2004, 42(7): 401-416.
[50]   Fregni F, Boggio PS, Lima MC, et al. A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain. 2006, 122(1-2): 197-209.
[51]   Harkema S, Gerasimenko Y, Hodes J, et al. Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study. Lancet. 2011, 377(9781): 1938-1947.
[52]   Soler MD, Kumru H, Pelayo R, et al. Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain in spinal cord injury. Brain. 2010, 133(9): 2565-2577.
[53]   Kern H, Carraro U, Adami N, et al. Home-based functional electrical stimulation rescues permanently denervated muscles in paraplegic patients with complete lower motor neuron lesion. Neurorehabil Neural Repair. 2010, 24(8): 709-721.
[54]   Angeli CA, Boakye M, Morton RA, et al. Recovery of over-ground walking after chronic motor complete spinal cord injury. N Engl J Med. 2018, 379(13): 1244-1250.
[55]   Gill ML, Grahn PJ, Calvert JS, et al. Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia. Nat Med. 2018, 24(11): 1677-1682.
[56]   Simeral JD, Kim SP, Black MJ, et al. Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array. J Neural Eng. 2011, 8(2): 025027
[57]   Hochberg LR, Bacher D, Jarosiewicz B, et al. Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. Nature. 2012, 485(7398): 372-375.
[58]   Onose G, Grozea C, Anghelescu A, et al. On the feasibility of using motor imagery EEG-based brain-computer interface in chronic tetraplegics for assistive robotic arm control: A clinical test and long-term post-trial follow-up. Spinal Cord. 2012, 50(8):599-608.
[59]   Collinger JL, Wodlinger B, Downey JE, et al. High- performance neuroprosthetic control by an individual with tetraplegia. Lancet.2012, pii: S0140-6736(12)61816-9.
[60]   Mignardot JB, Le Goff CG, van den Brand R, et al. A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury. Sci Transl Med. 2017, 9(399): eaah3621.
[61]   Bryukhovetskiy. Tissue Engineering in Neurorestoratology. Huang H, Raisman G, Sanberg PR, Sharma H, Chen L, eds. New York, Nova Biomedical, 2015.
[62]   Zhao Y, Tang F, Xiao Z, et al. Clinical study of neuroregen scaffold combined with human mesenchymal stem cells for the repair of chronic complete spinal cord injury. Cell Transplant. 2017, 26(5): 891-900.
[63]   Kucher K, Johns D, Maier D, et al. First-in-man intrathecal application of neurite growth-promoting Anti-Nogo-A antibodies in acute spinal cord injury. Neurorehabil Neural Repair. 2018, 32(6–7): 578-589.
[64]   McDonald JW, Becker D, Sadowsky CL, et al. Late recovery following spinal cord injury.Case report and review of the literature. J Neurosurg. 2002, 97(2 ): 252-265.
[65]   Harness ET, Yozbatiran N, Cramer SC. Effects of intense exercise in chronic spinal cord injury. Spinal Cord. 2008, 46(11): 733-737.
[66]   Manella KJ, Torres J, Field-Fote EC. Restoration of walking function in an individual with chronic complete (AIS A) spinal cord injury. J Rehabil Med. 2010, 42(8): 795-798.
[67]   Goldsmith HS, Neil-Dwyer G, Barsoum L. Omental transposition to the chronically injured human spinal cord. Paraplegia. 1986, 24(3): 173-174.
[68]   Cheng H, Liao KK, Liao SF, et al. Spinal cord repair with acidic fibroblast growth factor as a treatment for a patient with chronic paraplegia. Spine (Phila Pa 1976). 2004, 29(14): E284-288.
[69]   Steeves J, Fawcett J, Tuszynski M. Report of International Clinical Trials Workshop on Spinal Cord Injury February 20–21, 2004, Vancouver, Canada. Spinal Cord. 2004, 42: 591-597
[70]   Negrin J Jr. Spinal cord hypothermia in the neurosurgical management of the acute and chronic post-traumatic paraplegic patient. Paraplegia. 1973, 10(4): 336-343.
[71]   Gao X, Gao C, Gao J, et al. Acupuncture treatment of complete traumatic paraplegia—Analysis of 261 cases. J Tradit Chin Med. 1996, 16(2): 134-137.
[72]   Cheng PT, Wong MK, Chang PL. A therapeutic trial of acupuncture in neurogenic bladder of spinal cord injured patients—A preliminary report. Spinal Cord. 1998, 36(7): 476-480.
[73]   Moviglia GA, Varela G, Brizuela JA, et al. Case report on the clinical results of a combined cellular therapy for chronic spinal cord injured patients. Spinal Cord. 2009, 47(6): 499-503.
[74]   Seledtsova GV, Rabinovich SS, Belogorodtsev SN, et al. Delayed results of transplantation of fetal neurogenic tissue in patients with consequences of spinal cord trauma. Bull Exp Biol Med. 2010, 149(4): 530-533.
[75]   Geffner LF, Santacruz P, Izurieta M, et al. Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: Comprehensive case studies. Cell Transplant. 2008, 17(12): 1277-1293.
[76]   Bohbot A. Olfactory ensheathing glia transplantation combined with LASERPONCTURE in human spinal cord injury: Results measured by electromyography monitoring. Cell Transplant. 2010, 19(2): 179-184.
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