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Journal of Neurorestoratology  2018, Vol. 6 Issue (1): 171-178    doi: 10.26599/JNR.2018.9040013
Review Article     
Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses
Hongyun Huang1,2,(✉), Hari Shanker Sharma3, Lin Chen4, Ali Otom5, Ziad M. Al Zoubi6, Hooshang Saberi7, Dafin F. Muresanu8, Xijing He9
1 Institute of Neurorestoratology, Third Medical Center of PLA General Hospital, Beijing, China
2 Hongtianji Neuroscience Academy, Lingxiu building, Beijing, China
3 Intensive Experimental CNS Injury and Repair, University Hospital, UppsalaUniversity, Uppsala, Sweden
4 Department of Neurorestoratology, Tsinghua University Yuquan Hospital, Beijing, China
5 Royal Specialty Center for Spine and Musculoskeletal Disorders Amman, Jordan
6 Jordan Ortho and Spinal Centre, Al-Saif Medical Center, Amman, Jordan
7 Department of Neurosurgery, Brain and Spinal cord Injury Research center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
8 Department of Neurosciences “Iuliu Hatieganu,” University of Medicine and Pharmacy, Cluj-Napoca, Romania
9 Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
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Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies. In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords “neurorestorative strategies”, “spinal cord injury”, “cell therapy”, “neuromodulation”, and “nerve bridges”. Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.

Key wordsneurorestorative strategies      spinal cord injury      cell therapy      neuromodulation      nerve bridges     
Received: 01 December 2018      Published: 30 December 2018
Corresponding Authors: Hongyun Huang   
Cite this article:

Hongyun Huang, Hari Shanker Sharma, Lin Chen, Ali Otom, Ziad M. Al Zoubi, Hooshang Saberi, Dafin F. Muresanu, Xijing He. Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses. Journal of Neurorestoratology, 2018, 6: 171-178.

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