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Journal of Neurorestoratology  2020, Vol. 8 Issue (1): 53-59    doi: 10.26599/JNR.2019.9040018
Research Article     
Correlation between programmed stimulation parameters and their efficacy after deep brain electrode implantation for Parkinson’s disease
Jingchao Lu, Zhaohai Feng, Xin Shi, Lei Jiang, Yujun Hao(✉)
Department of Neurosurgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China
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Abstract  Purpose:

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an indispensable and effective surgery for patients with primary Parkinson’s disease (PD). Nonetheless, its postoperative effects can be decided by many factors including the optimal programmed stimulation parameters. In this study, we analyzed the correlation between different postoperative programmed stimulation parameters and their efficacy after STN–DBS electrode implantation in patients with PD.

Methods:

A total of 87 patients underwent electrode implantation and completed at least one year follow-up. Then, various combinations of stimulation parameters, including stimulus intensity, frequency, and pulse width, were examined for their effects on the clinical improvement of the patients. Improvements in motor and nonmotor symptoms were analyzed using Mini-Mental State Examination, Parkinson’s Disease Quality of Life Questionnaire-39, and Unified Parkinson’s Disease Rating Scale (UPDRS) scores before and after surgery.

Results:

We found significantly improved UPDRS scores, quality of life, and neuropsychiatric symptoms postoperatively considering the findings of the aforementioned stimulation parameters compared with those observed preoperatively.

Conclusion:

This study provides a better understanding on how programmed stimulation parameters help relieve PD symptoms and improve quality of life in patients with PD undergoing STN–DBS.



Key wordsParkinson’s disease      subthalamic nucleus      deep brain stimulation      programmed stimulation parameters     
Received: 24 July 2019      Published: 05 March 2020
Corresponding Authors: Yujun Hao, E-mail: hyj620530@vip.sohu.com    
Cite this article:

Jingchao Lu, Zhaohai Feng, Xin Shi, Lei Jiang, Yujun Hao. Correlation between programmed stimulation parameters and their efficacy after deep brain electrode implantation for Parkinson’s disease. Journal of Neurorestoratology, 2020, 8: 53-59.

URL:

http://jnr.tsinghuajournals.com/10.26599/JNR.2019.9040018     OR     http://jnr.tsinghuajournals.com/Y2020/V8/I1/53

Baseline demographic and clinical characteristics of the included patients with Parkinson’s disease (<i>n</i> = 87).
Deep brain stimulation parameters.
Efficacy scores after deep brain stimulation.
[1]   Muthuraman M, Deuschl G, Koirala N, et al. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Sci Rep. 2017, 7: 43571.
[2]   Hess CW, Hallett M. The phenomenology of Parkinson’s disease. Semin Neurol. 2017, 37(2): 109-117.
[3]   Graat I, Figee M, Denys D. The application of deep brain stimulation in the treatment of psychiatric disorders. Int Rev Psychiatry. 2017, 29(2): 178-190.
[4]   Parpaley Y, Skodda S. Deep brain stimulation in movement disorders: evidence and therapy standards. Fortschr Neurol Psychiatr. 2017, 85(7): 414-431.
[5]   Mideksa KG, Singh A, Hoogenboom N, et al. Comparison of imaging modalities and source-localization algorithms in locating the induced activity during deep brain stimulation of the STN. Conf Proc IEEE Eng Med Biol Soc. 2016, 2016: 105-108.
[6]   Dayal V, Limousin P, Foltynie T. Subthalamic nucleus deep brain stimulation in Parkinson’s disease: the effect of varying stimulation parameters. J Parkinsons Dis. 2017, 7(2): 235-245.
[7]   Hand A, Gray WK, Oates LL, et al. Medication use in people with late stage Parkinson’s disease and parkinsonism living at home and in institutional care in North-East England: A balance of symptoms and side-effects? Parkinsonism Relat Disord. 2016, 32: 120-123.
[8]   Bari AA, Fasano A, Munhoz RP, et al. Improving outcomes of subthalamic nucleus deep brain stimulation in Parkinson’s disease. Expert Rev Neurother. 2015, 15(10): 1151-1160.
[9]   Kobayashi M, Ohira T, Mihara B, et al. Changes in intracortical inhibition and clinical symptoms after STN-DBS in Parkinson’s disease. Clin Neurophysiol. 2016, 127(4): 2031-2037.
[10]   Huang CY, Chu HL, Zhang Y, et al. Deep brain stimulation to alleviate freezing of gait and cognitive dysfunction in Parkinson's disease: update on current research and future perspectives. Front Neurosci. 2018, 12: 29.
[11]   Amami P, Mascia MM, Franzini A, et al. Shifting from constant-voltage to constant-current in Parkinson’s disease patients with chronic stimulation. Neurol Sci. 2017, 38(8): 1505-1508.
[12]   Vallabhajosula S, Haq IU, Hwynn N, et al. Low- frequency versus high-frequency subthalamic nucleus deep brain stimulation on postural control and gait in Parkinson’s disease: a quantitative study. Brain Stimul. 2015, 8(1): 64-75.
[13]   Zibetti M, Moro E, Krishna V, et al. Low-frequency subthalamic stimulation in Parkinson’s disease: long- term outcome and predictors. Brain Stimul. 2016, 9(5): 774-779.
[14]   Whitmer D, de Solages C, Hill B, et al. High frequency deep brain stimulation attenuates subthalamic and cortical rhythms in Parkinson’s disease. Front Hum Neurosci. 2012, 6: 155.
[15]   Dayal V, Grover T, Limousin P, et al. The effect of short pulse width settings on the therapeutic window in subthalamic nucleus deep brain stimulation for Parkinson’s disease. J Parkinsons Dis. 2018, 8(2): 273-279.
[16]   Bouthour W, Wegrzyk J, Momjian S, et al. Short pulse width in subthalamic stimulation in Parkinson’s disease: a randomized, double-blind study. Mov Disord. 2018, 33(1): 169-173.
[17]   Steigerwald F, Timmermann L, Kühn A, et al. Pulse duration settings in subthalamic stimulation for Parkinson’s disease. Mov Disord. 2018, 33(1): 165-169.
[18]   Khojandi A, Shylo O, Mannini L, et al. Stratifying Parkinson’s patients with STN-DBS into high- frequency or 60 hz-frequency modulation using a computational model. Neuromodulation. 2017, 20(5): 450-455.
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