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Journal of Neurorestoratology  2020, Vol. 8 Issue (1): 53-59    doi: 10.26599/JNR.2019.9040018
Research Article     
Correlation between programmed stimulation parameters and their efficacy after deep brain electrode implantation for Parkinson’s disease
Jingchao Lu, Zhaohai Feng, Xin Shi, Lei Jiang, Yujun Hao(✉)
Department of Neurosurgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China
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Abstract  Purpose:

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an indispensable and effective surgery for patients with primary Parkinson’s disease (PD). Nonetheless, its postoperative effects can be decided by many factors including the optimal programmed stimulation parameters. In this study, we analyzed the correlation between different postoperative programmed stimulation parameters and their efficacy after STN–DBS electrode implantation in patients with PD.


A total of 87 patients underwent electrode implantation and completed at least one year follow-up. Then, various combinations of stimulation parameters, including stimulus intensity, frequency, and pulse width, were examined for their effects on the clinical improvement of the patients. Improvements in motor and nonmotor symptoms were analyzed using Mini-Mental State Examination, Parkinson’s Disease Quality of Life Questionnaire-39, and Unified Parkinson’s Disease Rating Scale (UPDRS) scores before and after surgery.


We found significantly improved UPDRS scores, quality of life, and neuropsychiatric symptoms postoperatively considering the findings of the aforementioned stimulation parameters compared with those observed preoperatively.


This study provides a better understanding on how programmed stimulation parameters help relieve PD symptoms and improve quality of life in patients with PD undergoing STN–DBS.

Key wordsParkinson’s disease      subthalamic nucleus      deep brain stimulation      programmed stimulation parameters     
Received: 24 July 2019      Published: 05 March 2020
Corresponding Authors: Yujun Hao, E-mail:    
Cite this article:

Jingchao Lu, Zhaohai Feng, Xin Shi, Lei Jiang, Yujun Hao. Correlation between programmed stimulation parameters and their efficacy after deep brain electrode implantation for Parkinson’s disease. Journal of Neurorestoratology, 2020, 8: 53-59.

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Baseline demographic and clinical characteristics of the included patients with Parkinson’s disease (<i>n</i> = 87).
Deep brain stimulation parameters.
Efficacy scores after deep brain stimulation.
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