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Journal of Neurorestoratology  2019, Vol. 7 Issue (4): 196-206    doi: 10.26599/JNR.2019.9040024
Review Article     
Progress in research into spinal cord injury repair: Tissue engineering scaffolds and cell transdifferentiation
Changke Ma1, Peng Zhang2, Yixin Shen2,(✉)
1 Department of Orthopaedics, The People's Hospital of Luhe, Nanjing 211500, Jiangsu, China
2 Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China
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As with all tissues of the central nervous system, the low regeneration ability of spinal cord tissue after injury decreases the potential for repair and recovery. Initially, in spinal cord injuries (SCI), often the surgeon can only limit further damage by early surgical decompression. However, with the development of basic science, especially the development of genetic engineering, molecular biology, tissue engineering, and materials science, some promising progress has been made in promoting the repair of central nervous system injuries. For example, transplantation of neural stem cells (NSCs), olfactory ensheathing cells (OECs), and gene- mediated transdifferentiation to repair central nervous system injury. This paper summarizes the progress and prospects of SCI repair with tissue engineering scaffold and cell transdifferentiation from an extensive literatures.

Key wordsspinal cord injury      stem cells      olfactory ensheathing cells      hydrogel      transdifferentiation     
Received: 19 September 2019      Published: 17 January 2020
Corresponding Authors: Yixin Shen   
Cite this article:

Changke Ma, Peng Zhang, Yixin Shen. Progress in research into spinal cord injury repair: Tissue engineering scaffolds and cell transdifferentiation. Journal of Neurorestoratology, 2019, 7: 196-206.

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