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Journal of Neurorestoratology  2020, Vol. 8 Issue (2): 61-82    doi: 10.26599/JNR.2020.9040009
Review Article     
Clinical neurorestorative cell therapies: Developmental process, current state and future prospective
Hongyun Huang1,2,*, Lin Chen3, Gengsheng Mao1, Hari Shanker Sharma4
1 Institute of Neurorestoratology, The Third Medical Centre, Chinese PLA General Hospital, Beijing 100853, China
2 Beijing Hongtianji Neuroscience Academy, Beijing 100144, China
3 Department of Neurosurgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine Beijing 100007, China
4 Int. Exp. CNS Injury & Repair, Neurobiology (MRC) & Neuroanatomy (UU), Uppsala University, University Hospital, Anesthesiology & Intensive Care Medicine, Dept. Surgical Sciences, Uppsala, Sweden
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Abstract  

Clinical cell therapies (CTs) for neurological diseases and cellular damage have been explored for more than 2 decades. According to the United States Food and Drug Administration, there are 2 types of cell categories for therapy, namely stem cell-derived CT products and mature/functionally differentiated cell-derived CT products. However, regardless of the type of CT used, the majority of reports of clinical CTs from either small sample sizes based on single-center phase 1 or 2 unblinded trials or retrospective clinical studies showed effects on neurological improvement and the ability to either partially or temporarily thwart the deteriorating cellular processes of the neurodegenerative diseases. There have been only a few prospective, multicenter, randomized, double- blind placebo-control clinical trials of CTs so far in this developing novel area that have shown negative results, and more clinical trials are needed. This will expand our knowledge in exploring the type of cells that yield promising results and restore damaged neurological structure and functions of the central nervous system based on higher level evidence-based medical data. In this review, we briefly introduce the developmental process, current state, and future prospective for clinical neurorestorative CT.



Key wordscell therapy      mature/functional cells      neurorestoration      olfactory ensheathing cells      stem cell-derived cell therapy product     
Received: 10 May 2020      Published: 11 August 2020
Corresponding Authors: Hongyun Huang   
Cite this article:

Hongyun Huang, Lin Chen, Gengsheng Mao, Hari Shanker Sharma. Clinical neurorestorative cell therapies: Developmental process, current state and future prospective. Journal of Neurorestoratology, 2020, 8: 61-82.

URL:

http://jnr.tsinghuajournals.com/10.26599/JNR.2020.9040009     OR     http://jnr.tsinghuajournals.com/Y2020/V8/I2/61

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[1] Xiaoling Guo, Qun Xue, Jianhua Zhao, Yi Yang, Yang Yu, Dezhong Liu, Jing Liu, Wenwu Yang, Linsen Mu, Ping Zhang, Tianyi Wang, Hongyan Han, Shoufeng Liu, Yuhua Zhu, Tao Wang, Chuanqiang Qu, Chuanqiang Qu. Clinical diagnostic and therapeutic guidelines of stroke neurorestoration (2020 China version)[J]. Journal of Neurorestoratology, 2020, 8(4): 241-251.
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[7] Gengsheng Mao, Yunliang Wang, Xiaoling Guo, Jun Liu, Zuncheng Zheng, Lin Chen. Neurorestorative effect of olfactory ensheathing cells and Schwann cells by intranasal delivery for patients with ischemic stroke: design of a multicenter randomized double-blinded placebo-controlled clinical study[J]. Journal of Neurorestoratology, 2018, 6(1): 74-80.
[8] Zhongju Shi, Zhijian Wei, Shiqing Feng, Gustavo Moviglia, Lin Chen, Ping Wu. Highlights for the 10th Annual Conference of the International Association of Neurorestoratology[J]. Journal of Neurorestoratology, 2018, 6(1): 84-87.
[9] Andrey S. Bryukhovetskiy. Translational experience of 28 years of use of the technologies of regenerative medicine to treat complex consequences of the brain and spinal cord trauma: Results, problems and conclusions[J]. Journal of Neurorestoratology, 2018, 6(1): 99-114.
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[13] Hongyun Huang, Lin Chen, Qingyan Zou, Fabin Han, Tiansheng Sun, Gengsheng Mao, Xijing He. Clinical cell therapy guidelines for neurorestoration (China version 2016)[J]. Journal of Neurorestoratology, 2017, 5(1): 39-46.
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