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Journal of Neurorestoratology  2020, Vol. 8 Issue (4): 252-269    doi: 10.26599/JNR.2020.9040022
Review Article     
The progress of biomaterials in peripheral nerve repair and regeneration
Yimeng Wang1(),Yuan Zhang2(),Xuemin Li1,(✉)(),Qiqing Zhang1,3,(✉)()
1 The Key Laboratory of Biomedical Material of Tianjin, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Biomedical Engineering, Tianjin 300192, China
2 Fujian Bote Biotechnology Co., Ltd., Fuzhou 350013, Fujian, China
3 Institute of Biomedical Engineering, Shenzhen People’s Hospital (Second Clinical Medical College of Jinan University), Shenzhen 518020, Guangdong, China
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Abstract  

Repair and regeneration of the injured peripheral nerve (PN) is a challenging issue in clinics. Although the regeneration outcome of large PN defects is currently unsatisfactory, recently, the study of PN repair has considerably progressed. In particular, biomaterials for repairing PNs, such as nerve guidance conduits and nerve repair membranes, have been well developed. Herein, we summarize the anatomy of the PN, the pathophysiological features of the nerve injury, and the repair process post injury. Then, we highlight the progress in the development of natural and synthetic biomaterials and summarize the applications, advantages, and disadvantages of these materials. These materials can be used as nerve repair membranes and nerve conduits in the field of PN repair. Finally, we discuss the challenges encountered and development strategies for PN repair in the future.



Key wordsperipheral nerve      nerve repair and regeneration      biomaterials      nerve conduits      tissue engineering     
Received: 10 September 2020      Published: 07 February 2021
Fund:  National Key Research and Development Program of China during the 13th Five-Year Plan Period(2017YFC1103600)
Corresponding Authors: Xuemin Li,Qiqing Zhang     E-mail: mmywm0496@163.com;zhangy@gtrbio.cn;lixuemin-7205@vip.sina.com;zhangqiq@126.com
Cite this article:

Yimeng Wang,Yuan Zhang,Xuemin Li,Qiqing Zhang. The progress of biomaterials in peripheral nerve repair and regeneration. Journal of Neurorestoratology, 2020, 8: 252-269.

URL:

http://jnr.tsinghuajournals.com/10.26599/JNR.2020.9040022     OR     http://jnr.tsinghuajournals.com/Y2020/V8/I4/252

Fig. 1Schematic of the anatomy of a normal peripheral nerve (PN).
Fig. 2Schematic of the expected functions and characteristics of nerve conduits for PN repair.
MaterialTypeApplicationPros and consReference
Polyglycolic acid (PGA)SyntheticNerve conduitsStable[24,48,64,65]
Nerve allograftsBiodegradable
Polylactic acid (PLA)SyntheticNerve conduitsEasy to fabricate[24,48,64,66]
NanoparticlesBiocompatible
Poly(L-lactide-co-ε-caprolactone) (PLCL)SyntheticNerve conduitsLow immunogenicity, Biocompatible[24,48,64]
CollagenNaturalNerve conduitsDegradable[24,44,47,48,67,68]
MembraneBiocompatible
Fibrin glueBioactivity, Immunogenic response
ChitosanNaturalNerve conduitsWeak degradability[24,46,48,67,68]
MembraneLow structural integrity
Silk fibroinNaturalNerve conduitsBiodegradable, Biocompatible, High structural integrity[24,48,67,68]
Table 1Application, advantages, and disadvantages of different materials.
ResearcherMaterialMethodResults
Junggeon Park, et. al.[103]Gelatin methacryloyl (GelMA)Fabricating conductive hydrogel-based nerve guidance conduits (NGCs) using GelMA and graphene oxideFacilitating neural regrowth, myelination, and functional regeneration
Neshat Askarzadeh, et al.[104]Polycaprolactone (PCL)Using PCL and N,N′-disuccinimidyl carbonate (DSC) cross-linked sodium alginate to fabricate a bilayer nerve conduit (named as P-CA)P-CA conduit promotes the migration of Schwann cells along the axon
Maliheh Jahromi, et al.[105]Poly(L-lactide-co-glycolide) (PLGA)Gold nanoparticles (AuNPs) and brain-derived neurotrophic factor (BDNF)-encapsulated chitosan in laminin-coated nanofiber of PLGA conduitEnhancing axonal regeneration and remyelination
Akram Abdo Almansoori, et al.[106]Poly(L-lactic acid) (PLLA)Constructing a nerve conduit made of PLLA (outer layer) and tantalum (Ta; inner layer)Ta-PLLA nerve conduit induces peripheral nerve regeneration without scar tissue formation
Pouria Ebrahimi-Zadehlou, et al.[107]Chitosan10-mm sciatic nerve defects were bridged using a chitosan conduit and 100 μL silymarin nanoparticles were administered into the conduit.Silymarin nanoparticles loaded into the chitosan conduit improved functional recovery of transected sciatic nerve in rats
Piao Wang, et al.[108]CollagenUsing a collagen conduit with basic fibroblast growth factorPromoting functional facial nerve recovery
Table 2Research status of various nerve conduits.
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