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    Volume 9 No. 1
    05 March 2021
    The 2020 Yearbook of Neurorestoratology
    Hongyun Huang,Lin Chen,Michael Chopp,Wise Young,John Robert Bach,Xijing He,Anna Sarnowaska,Mengzhou Xue,Robert Chunhua Zhao,Ashok Shetty,Dario Siniscalco,Xiaoling Guo,Alireza Khoshnevisan,Ziad Hawamdeh
    2021, 9(1):  1-12.  doi:10.26599/JNR.2021.9040002
    Abstract ( 58 )   HTML ( 4)   PDF (757KB) ( 105 )  
    COVID-19 has been an emerging and rapidly evolving risk to people of the world in 2020. Facing this dangerous situation, many colleagues in Neurorestoratology did their best to avoid infection if themselves and their patients, and continued their work in the research areas described in the 2020 Yearbook of Neurorestoratology. Neurorestorative achievements and progress during 2020 includes recent findings on the pathogenesis of neurological diseases, neurorestorative mechanisms and clinical thera...
    Standards of induced pluripotent stem cells derived clinical-grade neural stem cells preparation and quality control (2021 China version)
    Meng Cai, Fabin Han, Nanxiang Xiong, Yihao Wang, Shiqing Feng, Jiajing Wang, Xiang Li, Jun Wei, Changkai Sun
    2021, 9(1):  13-30.  doi:10.26599/JNR.2021.9040005
    Abstract ( 63 )   HTML ( 5)   PDF (858KB) ( 99 )  
    Induced pluripotent stem cells (iPSCs) have become the leading research object in the clinical application of restorative medicine. They are easily generated from diverse cell sources and functionally indistinguishable from embryonic stem cells without the accompanying ethical issues. To date, the use of iPSC-derived neural stem cells and their progeny in the treatment of neurodegenerative and injurious diseases has achieved good results, with great potential in cell drug development. However, b...
    Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)
    Xiaodong Guo, Yaping Feng, Tiansheng Sun, Shiqing Feng, Jiaguang Tang, Lin Chen, Xiaojian Cao, Haodong Lin, Xijing He, Meihua Li, Zhicheng Zhang, Guoyong Yin, Xifan Mei, Hongyun Huang
    2021, 9(1):  31-49.  doi:10.26599/JNR.2021.9040003
    Abstract ( 88 )   HTML ( 6)   PDF (919KB) ( 121 )  
    Treatment of spinal cord injury (SCI) remains challenging. Considering the rapid developments in neurorestorative therapies for SCI, we have revised and updated the Clinical Therapeutic Guidelines for Neurorestoration in Spinal Cord Injury (2016 Chinese version) of the Chinese Association of Neurorestoratology (Preparatory) and China Committee of International Association of Neurorestoratology. Treatment of SCI is a systematic multimodal process that aims to improve survival and restore neurolog...
    Clinical diagnosis guidelines and neurorestorative treatment for chronic disorders of consciousness (2021 China version)
    Yusheng Li, Jianghong He, Bo Yang, Hui Zhang, Zhonghua Yang, Jianhui Fu, Lian Huang, Hong Chen, Xiaofeng Yang, Yijun Bao
    2021, 9(1):  50-59.  doi:10.26599/JNR.2021.9040006
    Abstract ( 53 )   HTML ( 1)   PDF (822KB) ( 105 )  
    Chronic disorders of consciousness (DOC) include the vegetative state and the minimally consciousness state. The DOC diagnosis mainly relies on the evaluation of clinical behavioral scales, electrophysiological testing, and neuroimaging examinations. No specifically effective neurorestorative methods for chronic DOC currently exist. Any valuable exploration therapies of being able to repair functions and/or structures in the consciousness loop (e.g., drugs, hyperbaric medicines, noninvasive neur...
    Acupuncture treatment for spasticity after brain injury
    Rong Xie,Yifei Wang,Jianghong He,Yi Yang
    2021, 9(1):  60-71.  doi:10.26599/JNR.2021.9040001
    Abstract ( 33 )   HTML ( 0)   PDF (878KB) ( 81 )  
    Spasticity after brain injury is a neurological sequela caused by damage to upper motor neurons. The primary symptoms are involuntary muscle activity, decreased muscle strength, and joint contracture. Acupuncture as a therapeutic method to regulate central nervous system function has been studied widely in recent years. Many clinical experiments have proved that acupuncture has positive effects on spasticity after brain injury. In this review, we discuss recent research of acupuncture treatment ...
    Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat
    Silvia G. Ratti,Osvaldo J. Sacchi,Edgardo O. Alvarez
    2021, 9(1):  72-80.  doi:10.26599/JNR.2021.9040004
    Abstract ( 27 )   HTML ( 1)   PDF (1460KB) ( 70 )  
    In studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation, and prepuberal stages of litter (F1 generation) modified the behavioral patterns of motivated exploration, lateralized exploration, social activity, and survival responses of maturing rats. To determine whether these affected behaviors would extend to the next generation, F1 litter rats previously exposed to tellurium (Te) up to 30-day-old were left at rest with no further treatment up to 90-day-old....