Table of contents Previous Issue  

    Volume 07 No. 04
    05 December 2019
    Research and application progress on dural substitutes
    Weizuo Wang, Qiang Ao
    2019, 07(04):  161-170.  doi:10.26599/JNR.2019.9040020
    Abstract ( 39 )   HTML ( 0)   PDF (643KB) ( 9 )  
    Dural defects are a common problem in clinical practice, and various types of dural substitutes have been used to deal with dural defects. These play an important role in dural repair. Dural substitutes have gradually reached researchers, neurosurgeons, and patients for approval. This article summarizes the structural characteristics of the dura mater and its regeneration after injury, and reviews the state of progress in research and application. It will provide a reference for the development ...
    Advances in biomarkers of cerebral small vessel disease
    Xue Peng, Jianhua Zhao, Junli Liu, Shaomin Li
    2019, 07(04):  171-183.  doi:10.26599/JNR.2019.9040021
    Abstract ( 31 )   PDF (743KB) ( 36 )  
    Cerebral small vessel disease (CSVD) refers to a type of syndrome caused by lesions in perforating arteries, small veins, small arteries, or capillaries, resulting in clinical, imaging, or pathological alterations. The occurrence and development of CSVD are related to various cerebrovascular risk factors, such as metabolism and genetic factors. CSVD is diagnosed based on brain imaging biomarkers; however, biomarkers capable of predicting and diagnosing CSVD early in its progression have not been...
    Cerebral small vessel disease and cognitive impairment
    Lifang Meng, Jianhua Zhao, Junli Liu, Shaomin Li
    2019, 07(04):  184-195.  doi:10.26599/JNR.2019.9040023
    Abstract ( 0 )   PDF (677KB) ( 0 )  
    Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets. Imaging features vary; they are mainly composed of recent subcortical infarcts, lacunes of presumed vascular origin, white matter hyperintensities (WMHs) of presumed vascular origin, cerebral microbleeds, enlarged perivascular spaces, and global and regional brain atrophy. CSVD is a common cause of vascular cognitive dysfunction, and in...
    Progress in research into spinal cord injury repair: Tissue engineering scaffolds and cell transdifferentiation
    Changke Ma, Peng Zhang, Yixin Shen
    2019, 07(04):  196-206.  doi:10.26599/JNR.2019.9040024
    Abstract ( 2 )   HTML ( 0)   PDF (690KB) ( 2 )  
    As with all tissues of the central nervous system, the low regeneration ability of spinal cord tissue after injury decreases the potential for repair and recovery. Initially, in spinal cord injuries (SCI), often the surgeon can only limit further damage by early surgical decompression. However, with the development of basic science, especially the development of genetic engineering, molecular biology, tissue engineering, and materials science, some promising progress has been made in promoting t...
    Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease
    Zhu Zhang, Shiqing Zhang, Cathy Nga-Ping Lui, Peili Zhu, Zhang Zhang, Kaili Lin, Yiwu Dai, Ken Kin-Lam Yung
    2019, 07(04):  207-222.  doi:10.26599/JNR.2019.9040026
    Abstract ( 2 )   HTML ( 0)   PDF (885KB) ( 0 )  
    The prevalence of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), has been dramatically increasing, particularly in the aging population. However, the currently available therapies merely alleviate the symptoms of these diseases and are unable to retard disease progression significantly. Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years for ameliorating symptoms or interfering with the pathogenesis of ...
    Lateralized spontaneous exploratory behavior in maturing rats induced by new geometrically differentiated environments after administration with trace elements
    Silvia G. Ratti, Osvaldo J. Sacchi, Edgardo O. Alvarez
    2019, 07(04):  223-234.  doi:10.26599/JNR.2019.9040022
    Abstract ( 29 )   HTML ( 0)   PDF (1107KB) ( 20 )  
    Functional laterality is known as an intrinsic property of the brain. Since several studies have shown the presence of laterality in many species other than humans, it has been suggested that this is an adaptive mechanism to aid survival. Previous studies have shown that lateralized behavior observed during exposure to different environmental stimuli is not constant in normal animals, depending on the geometrical form of the exploratory field. In these exploratory fields, animals showed right- o...
    Small ruptured and unruptured complex cerebral aneurysms: Single center experience of low-profile visualized intraluminal support stent
    Xianli Lv, Chuhan Jiang, Shikai Liang
    2019, 07(04):  235-241.  doi:10.26599/JNR.2019.9040025
    Abstract ( 2 )   HTML ( 0)   PDF (3160KB) ( 0 )  
    Objectives:Even though low-profile visualized intraluminal support (LVIS) device is used extensively currently and provide intraluminal support in complex cerebral aneurysm embolization, only few studies have reported its clinical results. This study presents the results of patients treated with LVIS.Patients and methods:Cerebral aneurysms with an undefined neck, fusiform shape, and blood blister-like aneurysms that were treated with LVIS between May 2017 and May 2019 were reviewed retrospective...