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Journal of Neurorestoratology  2017, Vol. 5 Issue (1): 125-131    doi: 10.2147/JN.S139677
Review     
Stem cell-based therapies to treat spinal cord injury: a review
Zhongju Shi1,2, Hongyun Huang3, Shiqing Feng1,2
1 Department of Orthopaedics, Tianjin Medical University General Hospital;
2 Institute of Neurology, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin City, Tianjin;
3 Institute of Neurorestoratology, General Hospital of Armed Police Forces, Beijing, People’s Republic of China
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Abstract  Spinal cord injury (SCI) is a devastating condition and major burden on society and individuals. Currently, neurorestorative strategies, including stem cell therapy products or mature/functionally differentiated cell-derived cell therapy products, can restore patients with chronic complete SCI to some degree of neurological functions. The stem cells for neurorestoration include neural stem cells, mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, etc. A better understanding of the merits, demerits and precise function of different stem cells in the treatment of SCI may aid in the development of neurorestorative strategies. However, the efficacy, safety and ethical concerns of stem cell-based therapy continue to be challenged. Nonetheless, stem cell-based therapies hold promise of widespread applications, particularly in areas of SCI, and have the potential to be novel therapeutics, which contributes to the repair of SCI. This review mainly focused on recent advances regarding the stem cell-based therapies in the treatment of SCI and discussed future perspectives in this field.

Key wordsspinal cord injury      neural stem cells      bone marrow-derived mesenchymal stem cells      adipose-derived stem cells      embryonic stem cells      induced pluripotent stem cells     
Received: 14 April 2017      Published: 26 December 2017
Corresponding Authors: Shiqing Feng, Department of Orthopaedics, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, People’s Republic of China Tel/Fax +86 22 2718 3812 Email sqfeng@tmu.edu.cn   
Cite this article:

Zhongju Shi, Hongyun Huang, Shiqing Feng. Stem cell-based therapies to treat spinal cord injury: a review. Journal of Neurorestoratology, 2017, 5: 125-131.

URL:

http://jnr.tsinghuajournals.com/10.2147/JN.S139677     OR     http://jnr.tsinghuajournals.com/Y2017/V5/I1/125

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