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Journal of Neurorestoratology  2019, Vol. 7 Issue (2): 82-88    doi: 10.26599/JNR.2019.9040009
Research Article     
Olfactory ensheathing cell transplantation improving cerebral infarction sequela: a case report and literature review
Xiaoling Guo1,(✉), Xin Wang1,2, Yan Li1, Bo Zhou1,2, Weidong Chen3, Lihua Ren3
1 Department of Neurology, The 981st Hospital of the Chinese People's Liberation Army, Chengde 067000, Hebei, China
2 Chengde Medical University, Chengde 067000, Hebei, China
3 Otorhinolaryngology Department, The 981st Hospital of the Chinese People's Liberation Army, Chengde 067000, Hebei, China
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Abstract  

Stroke is the second leading cause of death and the main cause of long-term disability in the world. Therefore, treatment of the sequelae of stroke is one of the most important challenges in clinical neurotherapy. A 63-year-old Chinese woman with inarticulateness and right limb physical activity disorder for more than 4 months received olfactory ensheathing cells (OECs)-based neurorestorative therapy during the stay in hospital. Her neurological functions improved during 1-year follow-up. This case report showed that OECs therapy could be a treatment option for cerebral infarction sequela.



Key wordsolfactory ensheathing cell (OEC)      stroke      cell therapy      Neurorestoratology     
Received: 10 April 2019      Published: 03 June 2019
Corresponding Authors: Xiaoling Guo   
Cite this article:

Xiaoling Guo, Xin Wang, Yan Li, Bo Zhou, Weidong Chen, Lihua Ren. Olfactory ensheathing cell transplantation improving cerebral infarction sequela: a case report and literature review. Journal of Neurorestoratology, 2019, 7: 82-88.

URL:

http://jnr.tsinghuajournals.com/10.26599/JNR.2019.9040009     OR     http://jnr.tsinghuajournals.com/Y2019/V7/I2/82

Fig. 1MRI and MRA. (A) and (B) are the patient's MRI images (A, T1; B, T2) (1 month before OECs treatment). (C) is the patient's MRA image.
Fig. 2OECs are showed in red (P75+, 100×).
Fig. 3Nasal olfactory submucosal injection of OECs.
Muscle strength (level)Before treatment1 month after treatment3 months after treatment6 months after treatment1 year after treatment
Proxima of right upper limb333+4?4+
Distal of right upper limb00223
Right lower limb4?444+4+
Table 1The results of muscle strength measurement.
Before treatment1 month after treatment3 months after treatment6 months after treatment1 year after treatment
NIHSS (score)1010977
Modified Rankin Score (score)43322
Barthel Index Score (score)6060708590
Modified Ashworth Score (level)11111
Table 2The results of NIHSS, Modified Rankin Score, Barthel Index Score and Modified Ashworth Score.
Fig. 4The images of MRI 1 year after OECs treatment. (A) T1; (B) T2.
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