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    Volume 1 No. 1
    26 December 2013
    Lipoic acid enhances survival of transplanted neural stem cells by reducing transplantation-associated injury
    Junling Gao,Jason R Thonhoff,Tiffany J Dunn, Ping Wu
    2013, 1(1):  1-12.  doi:10.2147/JN.S43745
    Abstract ( 45 )   PDF (4178KB) ( 11 )  
    The efficacy of stem cell-based therapy for neurological diseases depends highly on cell survival post-transplantation. One of the key factors affecting cell survival is the grafting procedure. The current study aims to determine whether needle insertion into intact rat spinal cords creates a hypoxic environment that is prone to lipid peroxidation damage upon reperfusion, and whether an antioxidant protects human neural stem cells (hNSCs) both in vitro and post-transplantation into rat spinal co...
    Detailed analysis of the clinical effects of cell therapy for thoracolumbar spinal cord injury: an original study
    Alok Sharma, Nandini Gokulchandran, Hemangi Sane, Prerna Badhe, Pooja Kulkarni, Mamta Lohia, Anjana Nagrajan, Nancy Thomas
    2013, 1(1):  13-22.  doi:10.2147/JN.S43712
    Abstract ( 31 )   PDF (1458KB) ( 11 )  
    Background: Cell therapy is amongst the most promising treatment strategies in spinal cord injury (SCI) because it focuses on repair. There are many published animal studies and a few human trials showing remarkable results with various cell types. The level of SCI determines whether paraplegia or quadriplegia is present, and greatly influences recovery. The purpose of this study was to determine the significance of the clinical effects and long-term safety of intrathecal administration of autol...
    Human umbilical cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide intoxication
    Dianrong Gong, Haiyan Yu, Weihua Wang, Haixin Yang, Fabin Han
    2013, 1(1):  23-29.  doi:10.2147/JN.S47273
    Abstract ( 39 )   PDF (564KB) ( 10 )  
    Stem cell transplantation is one of the potential treatments for neurological disorders. Since human umbilical cord stem cells have been shown to provide neuroprotection and promote neural regeneration, we have attempted to transplant the human umbilical cord blood mononuclear cells (hUCB-MNCs) to treat patients with delayed encephalopathy after carbon monoxide intoxication (DEACOI). The hUCB-MNCs were isolated from fresh umbilical cord blood and were given to patients subarachnoidally. Physical...
    Motor improvement in cerebellar ataxia after integral rehabilitation
    Jorge L Jorge-Rodríguez, Elizabeth Fernández-Martínez, Daymi Rodríguez Pérez, Antonio Peralta-Flores, Jorge A Bergado
    2013, 1(1):  31-36.  doi:10.2147/JN.S49253
    Abstract ( 32 )   PDF (314KB) ( 13 )  
    Cerebellar ataxia is a complex motor impairment arising from neurologic disease. The dysfunction significantly impairs quality of movement, equilibrium, and gait. In this study, we evaluated motor function in 20 patients with acquired or degenerative ataxia undergoing rehabilitation using a program developed at the International Center for Restorative Neurology in Havana. All patients were evaluated before and 28 and 42 days after treatment using the International Cooperative Ataxia Rating Scale...
    Neurorestoratology: one of the most promising new disciplines at the forefront of neuroscience and medicine
    Hongyun Huang, Hari Shanker Sharma
    2013, 1(1):  37-41.  doi:10.2147/JN.S47592
    Abstract ( 41 )   PDF (2156KB) ( 10 )  
    Neurorestoratology is a new and emerging distinct discipline put forward on the basis of nervous restorable (neurorestorable) theory, which states that nerve damage to the central nervous system (CNS) can be restored. Neurorestorable theory in CNS was proposed by Huang et al based on clinical achievements obtained from cell-based neurorestorative therapy1. Neurorestoratology, same as neurology, neurosurgery, neurorehabilitation, etc is a distinct discipline in neuroscience and medicine. The Bei...
    Therapeutic effects of NogoA vaccine and olfactory ensheathing glial cell implantation on acute spinal cord injury
    Zhicheng Zhang, Fang Li, Tiansheng Sun, Dajiang Ren, Xiumei Liu
    2013, 1(1):  43-53.  doi:10.2147/JN.S47680
    Abstract ( 28 )   PDF (966KB) ( 10 )  
    Background: Many previous studies have focused on the effects of IN-1, a monoclonal antibody that neutralizes Nogo (a neurite growth inhibitory protein), on neurologic regeneration in spinal cord injury (SCI). However, safety problems and the short half-life of the exogenous antibody are still problematic. In the present study, the NogoA polypeptide was used as an antigen to make a therapeutic NogoA vaccine. Rats were immunized with this vaccine and were able to secrete the polyclonal antibody b...
    The role of hSCs in promoting neural differentiation of hUC-MSCs in spinal cord injury
    Qiuli Wu,You Chen,Guangzhi Ning, ,Shiqing Feng, ,Junling Han, ,Qiang Wu, Yulin LI, Hong Wu, Hongyu Shi
    2013, 1(1):  55-61.  doi:10.2147/JN.S47393
    Abstract ( 34 )   PDF (1142KB) ( 9 )  
    Cell therapy is a promising approach to treating spinal cord injury (SCI). Previous studies demonstrated that co-transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) and human Schwann cells (hSCs) was an effective strategy by which to promote the regeneration of corticospinal fibers and locomotor recovery after SCI in rats. However, the neural differentiation potential of hUC-MSCs was not fully understood. In the present study, we examined the influence of hSCs on the surviv...