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    Volume 7 No. 1
    22 March 2019
    Summary report of the 11th Annual Conference of International Association of Neurorestoratology (IANR)
    Lin Chen, Wise Young, Gustavo A. Moviglia, Ziad M. Al Zoubi
    2019, 7(1):  1-7.  doi:10.26599/JNR.2019.9040004
    Abstract ( 45 )   HTML ( 0)   PDF (722KB) ( 11 )  
    The 11th Annual Conference of the International Association of Neurorestoratology (IANR) was held from October 2nd to 4th at the University of Rutgers, New Jersey, USA, in which the most highlight was to report many frontier clinical trials. This summary report tries to display mainly presenting achievements in this conference.
    2018 Yearbook of Neurorestoratology
    Hongyun Huang, Hari Shanker Sharma, Lin Chen, Hooshang Saberi, Gengsheng Mao
    2019, 7(1):  8-17.  doi:10.26599/JNR.2019.9040003
    Abstract ( 131 )   HTML ( 1)   PDF (704KB) ( 168 )  
    The Neurorestoratology discipline is getting worldwide attention from the clinicians, basic scientists, students and policy makers alike. Accordingly, this year too, the discipline has made profound advances and great achievements for the benefit of the mankind. In this report, of the 2018 Neurorestoratology Yearbook, salient features of new developments are summarized. This Yearbook consists 3 key themes namely (i) the new findings on pathogenesis of neurological diseases or degeneration; (ii) ...
    Muse cells and Neurorestoratology
    Zikuan Leng, Nikhit Kethidi, Allen J. Chang, Lijun Sun, Jingjing Zhai, Yiting Yang, Jianzhong Xu, Xijing He
    2019, 7(1):  18-25.  doi:10.26599/JNR.2019.9040005
    Abstract ( 160 )   HTML ( 2)   PDF (783KB) ( 207 )  
    Multilineage-differentiating stress-enduring (Muse) cells were discovered in 2010 as a subpopulation of mesenchymal stroma cells (MSCs). Muse cells can self-renew and tolerate severe culturing conditions. These cells can differentiate into three lineage cells spontaneously or in induced medium but do not form teratoma in vitro or in vivo. Central nervous system (CNS) diseases, such as intracerebral hemorrhage (ICH), cerebral infarction, and spinal cord injury are normally disastrous. Despite num...
    Can phantom limb pain be reduced/eliminated solely by techniques applied to peripheral nerves?
    Damien P. Kuffler
    2019, 7(1):  26-36.  doi:10.26599/JNR.2019.9040002
    Abstract ( 114 )   HTML ( 1)   PDF (1061KB) ( 163 )  
    About 0.5% of the US population (1.7 million) is living with a lost limb and this number is expected to double by 2050. This number is much higher in other parts of the world. Within days to weeks of an extremity amputation, up to 80% of these individuals develop neuropathic pain presenting as phantom limb pain (PLP). The level of PLP increases significantly by one year and remains chronic and severe for about 10% of individuals. PLP has a serious negative impact on individuals’ lives. Current p...
    Differential effects of zinc and tellurium on epigenetic changes of coping behaviour in maturing rats
    Silvia G. Ratti, Edgardo O. Alvarez
    2019, 7(1):  37-46.  doi:10.26599/JNR.2019.9040001
    Abstract ( 80 )   HTML ( 0)   PDF (1425KB) ( 147 )  
    Trace element and its probable role in biological systems have attracted the attention of many researchers in recent years. Previous work has shown that ZnTe administered in drinking water to pregnant rats during pregnancy, delivery, lactation and offspring maturation up to prepuberal stage is able to modify several parameters of spontaneous behaviours related to cognition in offspring rats. Since Zn and Te have many biological properties, it’s not possible to conclude if behavioural changes are...
    Comparison of therapeutic effects of melatonin by two different routes in focal cerebral ischemic rats
    Lanfen Chen, Wei Chen, Mengbei Zhang, Dandan Cheng, Xiaoli Wang
    2019, 7(1):  47-53.  doi:10.26599/JNR.2019.9040006
    Abstract ( 102 )   HTML ( 0)   PDF (1771KB) ( 166 )  
    Objective:To explore the therapeutic effects of melatonin by two different routes, by caudal vein and intraperitoneal injection, on cerebral ischemia-reperfusion (IR) injury in adult rats.Methods:60 Sprague-Dawley rats were randomly divided into normal control (CON), middle cerebral artery occlusion (MCAO), intraperitoneal and caudal vein injection groups. Nissl and immunohistochemical staining were used to observe the morphological and quantitative changes of neurons and the expression of cleav...