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    Volume 7 No. 2
    05 June 2019
    The cell repair research of spinal cord injury: a review of cell transplantation to treat spinal cord injury
    Zhenrong Zhang, Fangyong Wang, Mingjie Song
    2019, 7(2):  55-62.  doi:10.26599/JNR.2019.9040011
    Abstract ( 422 )   HTML ( 21)   PDF (684KB) ( 506 )  
    Through retrospective analysis of the literature on the cell repair of spinal cord injury worldwide, it is found that the mechanism of cell transplantation repairing spinal cord injury is mainly to replace damaged neurons, protect host neurons, prevent apoptosis, promote axonal regeneration and synapse formation, promote myelination, and secrete trophic factors or growth factors to improve microenvironment. A variety of cells are used to repair spinal cord injury. Stem cells include multipotent ...
    Associated factors of early neurological deterioration in isolated acute lacunar infarction in basal ganglia
    Honghao Man, Yuhua Bi, Yongpeng Yu, Shengwu Wang, Zhenming Zhao, Xiaohong Qiao, Weiping Ju
    2019, 7(2):  63-69.  doi:10.26599/JNR.2019.9040007
    Abstract ( 164 )   HTML ( 5)   PDF (668KB) ( 253 )  
    Objective:To investigate, in basal ganglia, the factors associated with early neurological deterioration (END) of isolated acute lacunar infarction.Methods:167 patients, in the retrospective group, with isolated acute lacunar infarction in basal ganglia, were defined by magnetic resonance imaging (MRI). The National Institutes of Health Stroke Scale (NIHSS) defined early neurological deterioration as increases of ≥ 2 within 72 hours following admission. Baseline variables predicting END w...
    Application of olfactory ensheathing cells in clinical treatment of spinal cord injury: meta-analysis and prospect
    Huijing Chen, Qijia Tan, Caijun Xie, Cong Li, Yun Chen, Yuer Deng, Yanling Gan, Wengang Zhan, Zhiqiang Zhang, Aruna Sharma, Hari Sharma
    2019, 7(2):  70-81.  doi:10.26599/JNR.2019.9040008
    Abstract ( 203 )   HTML ( 8)   PDF (2324KB) ( 264 )  
    Background:A number of clinical trials of olfactory ensheathing cells (OECs) for the treatment of chronic spinal cord injury (SCI) have been carried out all over the world. However, their safety and efficacy have not been basically evaluated. Moreover, there are no uniform standards laid out for the use of optimal source, transplantation method and the dosage of OECs.Objective:This study evaluated the source, dose, and route of transplantation of OECs for the treatment of chronic SCI.Methods:Pub...
    Olfactory ensheathing cell transplantation improving cerebral infarction sequela: a case report and literature review
    Xiaoling Guo, Xin Wang, Yan Li, Bo Zhou, Weidong Chen, Lihua Ren
    2019, 7(2):  82-88.  doi:10.26599/JNR.2019.9040009
    Abstract ( 139 )   HTML ( 1)   PDF (1194KB) ( 237 )  
    Stroke is the second leading cause of death and the main cause of long-term disability in the world. Therefore, treatment of the sequelae of stroke is one of the most important challenges in clinical neurotherapy. A 63-year-old Chinese woman with inarticulateness and right limb physical activity disorder for more than 4 months received olfactory ensheathing cells (OECs)-based neurorestorative therapy during the stay in hospital. Her neurological functions improved during 1-year follow-up. This c...
    Intranasal delivery of M2 macrophage-derived soluble products reduces neuropsychological deficit in patients with cerebrovascular disease: a pilot study
    Ekaterina Shevela, Marina Davydova, Natalia Starostina, Alexandra Yankovskaya, Alexandr Ostanin, Elena Chernykh
    2019, 7(2):  89-100.  doi:10.26599/JNR.2019.9040010
    Abstract ( 234 )   HTML ( 8)   PDF (797KB) ( 323 )  
    Objective:We assessed the safety and clinical effectiveness of intranasal therapy with M2 macrophage-derived soluble products (M2-SPs) for treating patients with cerebrovascular disease (CVD).Materials and methods:The protocol of the study was registered at www.ClinicalTrails.gov (NCT02957123). The study group comprised 30 patients with chronic CVD. Neurological status was examined before therapy and at 1- and 6-month follow–up. Concentrations of 32 cytokines in the blood serum were evaluated be...
    Decreased Npas4 expression in patients with post-stroke depression
    Shina Gu, Xiaodan Li, Lin Zhao, Huicong Ren, Chendi Pei, Wenqiang Li, Junlin Mu, Jinggui Song, Zhaohui Zhang
    2019, 7(2):  101-108.  doi:10.26599/JNR.2019.9040012
    Abstract ( 224 )   HTML ( 5)   PDF (1163KB) ( 303 )  
    Purpose:Post-stroke depression (PSD) is a frequent neuropsychiatric disorder following stroke which is associated with poor outcome. Neuronal Per-Arnt-Sim (PAS) domain protein 4 (Npas4) is associated with cognitive function. Npas4 expression in peripheral blood mononuclear cells (PBMCs) from patients with PSD was measured to find new therapeutic strategy.Patients and methods:Ischemic stroke patients (n = 152) within 1 week of stroke onset were recruited. At 3 months follow-up, the patients were ...