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    Volume 8 No. 2
    05 June 2020
    Clinical neurorestorative cell therapies: Developmental process, current state and future prospective
    Hongyun Huang, Lin Chen, Gengsheng Mao, Hari Shanker Sharma
    2020, 8(2):  61-82.  doi:10.26599/JNR.2020.9040009
    Abstract ( 258 )   HTML ( 14)   PDF (959KB) ( 321 )  
    Clinical cell therapies (CTs) for neurological diseases and cellular damage have been explored for more than 2 decades. According to the United States Food and Drug Administration, there are 2 types of cell categories for therapy, namely stem cell-derived CT products and mature/functionally differentiated cell-derived CT products. However, regardless of the type of CT used, the majority of reports of clinical CTs from either small sample sizes based on single-center phase 1 or 2 unblinded trials...
    Chinese expert consensus on diagnosis and management of split cord malformation
    Bo Xiu, Fuyun Liu, Aijia Shang, Rui Zhang
    2020, 8(2):  83-92.  doi:10.26599/JNR.2020.9040010
    Abstract ( 180 )   HTML ( 2)   PDF (967KB) ( 250 )  
    Split cord malformation (SCM) is a neural tube defect that the spinal cord is longitudinally separated into two hemicords with individual functions, which causes severe spinal cord impairment and sensorimotor deficit. As a kind of myelodysplasia and a special type of tethered cord syndrome, SCM is not widely understood, and common issues in the diagnosis and treatment of SCM should be clarified. In this paper, the Chinese Split Cord Malformation Working Group made a consensus for SCM on embryopa...
    The cell repair research for Parkinson’s disease: A systematic review
    Chao Chen, Qingfa Chen, Yan Liu, Chongyang Zhang, Kaixiang Zhu, Xue Li, Haitao Xie, Rui Zhang
    2020, 8(2):  93-103.  doi:10.26599/JNR.2020.9040011
    Abstract ( 331 )   HTML ( 4)   PDF (1061KB) ( 219 )  
    Background and Objective:Parkinson’s disease (PD) is a common neurodegenerative disease. Previous studies have demonstrated the effect of cell-based therapies, but their clinical efficacy and safety have not been evaluated. This review protocol aimed to systematically evaluate the effect of stem cell therapy in patients with PD and to develop an evidence base for guiding policy and practice.Methods:PubMed, Embase, MedlinePlus, The Lancet and Brain were searched over the period January 2001 to Oc...
    Preoperative visualization of neurovascular contact with 3D-FIESTA combined with 3D-TOF MRA to guide microvascular decompression surgery planning
    Dezhong Liu, Pengfei Shi, Kai Li, Yazhou Guo, Xiao Liu, Changwei Wang, Yu Liu, Bing He, Xiaoyang Zhang
    2020, 8(2):  104-113.  doi:10.26599/JNR.2020.9040005
    Abstract ( 302 )   HTML ( 2)   PDF (7690KB) ( 260 )  
    Background:Neurovascular compression syndromes including trigeminal neuralgia (TN) and hemifacial spasm (HFS) are caused by neurovascular conflicts at the root entry zone of the corresponding cranial nerves in the posterior fossa. Microvascular decompression (MVD) is the best choice for the treatment of TN and HFS. An accurate delineation of the responsible vessel could decrease the rate of possible operative complications such as nerve paresis.Methods:In this study, three-dimensional fast imagi...
    Oxyhemoglobin desaturation as a function of age and hypercapnia from ventilatory pump failure (VPF)
    John R. Bach, Damian Pronello
    2020, 8(2):  114-121.  doi:10.26599/JNR.2020.9040013
    Abstract ( 128 )   HTML ( 0)   PDF (952KB) ( 225 )  
    Background:Supplemental O2 is often administered without knowledge of CO2 levels for patients with ventilatory pump failure (VPF). This can render oximetry ineffective as a gauge of alveolar ventilation, airway secretions, and lung disease. We have noted that diurnal hypoventilation with hypercapnia tends to be symptomatic when O2 saturation levels decrease below 95% and patients extend sleep noninvasive ventilatory support (NVS) into daytime hours. We also noted that with advancing age, less hy...
    Transplantation of umbilical cord blood mononuclear cells attenuates the expression of IL-1β via the TLR4/NF-κB pathway in hypoxic-ischemic neonatal rats
    Meng-Bei Zhang, Chao-Chao Song, Guang-Zu Li, Lan-Fen Chen, Rui Ma, Xiao-He Yu, Ping Gong, Xiao-Li Wang
    2020, 8(2):  122-130.  doi:10.26599/JNR.2020.9040015
    Abstract ( 198 )   HTML ( 4)   PDF (2891KB) ( 260 )  
    Objective:This study aims to observe the effects of transplantation of umbilical cord blood mononuclear cells (UCBMCs) on the expression of interleukin (IL)-1β and explore the mechanism via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway in hypoxic-ischemic neonatal rats.Methods:Seven-day-old Sprague-Dawley neonatal rats were randomly divided into Sham, hypoxic-ischemic brain damage (HIBD), and UCBMC groups. The HIBD model was prepared by Rice-Vannucci method...