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    Volume 8 No. 4
    30 December 2020
    Special issue on guidelines and standards in Neurorestoratology
    Lin Chen,Hongyun Huang
    2020, 8(4):  195-196.  doi:10.26599/JNR.2020.9040027
    Abstract ( 191 )   HTML ( 6)   PDF (221KB) ( 165 )  
    Standards of clinical-grade mesenchymal stromal cell preparation and quality control (2020 China Version)
    Shuanglin Xiang,Wenyong Gao,Haining Peng,Aibing Liu,Qiang Ao,Manjun Yang,Yanqiu Yu,Ying Liu,Raoxing Rong
    2020, 8(4):  197-216.  doi:10.26599/JNR.2020.9040021
    Abstract ( 228 )   HTML ( 6)   PDF (447KB) ( 213 )  
    Mesenchymal stromal cells (MSCs) including mesenchymal stem cells to potentially differentiate into different tissue lineages widely exist in various tissues. In recent years, the clinical research and application of MSCs have become more extensive, but no standardized guidelines for the preparation and quality control of clinical-grade MSCs currently exist. To standardize the preparation and quality control of MSCs using the human umbilical cord, placenta, bone marrow, and adipose tissue as sam...
    Standards of clinical-grade olfactory ensheathing cell culture and quality control (2020 China Version)
    Hongyun Huang,Wenyong Gao,Zhenghui Yan,Aibing Liu,Xijing He,Ming Lu,Ying Liu,Yixin Shen,Jianhua Zhao,Zuncheng Zheng,Tiansheng Sun,Yaojian Rao
    2020, 8(4):  217-231.  doi:10.26599/JNR.2020.9040023
    Abstract ( 142 )   HTML ( 0)   PDF (441KB) ( 188 )  
    Currently, there are many different standards for the quality control of olfactory ensheathing cell (OEC) culture prepared from human olfactory bulb and mucosa. It is challenging to compare the clinical results of OEC treatment from different hospitals. Based on various standards, the Chinese Association of Neurorestoratology (CANR; Preparatory) and China Committee of International Association of Neurorestoratology (IANR-China Committee) organized professional experts in this field to evaluate t...
    Clinical neurorestorative therapeutic guideline for brainstem hemorrhage (2020 China version)
    Lin Chen,Tao Chen,Gengsheng Mao,Baodong Chen,Mingchang Li,Hongbo Zhang,Haitao Xi,Xiaochun She,Zhouping Tang,Ping Zhang,Zhiqiang Zhang,Li Cong,Yijun Bao,Xiaofeng Yang,Siyuan Zhao,Chao He,Liang Wen,Ping Zhang,Mengzhou Xue
    2020, 8(4):  232-240.  doi:10.26599/JNR.2020.9040024
    Abstract ( 265 )   HTML ( 11)   PDF (369KB) ( 295 )  
    Brainstem hemorrhage (mainly pontine hemorrhage caused by hypertension) has the clinical characteristics of acute onset, rapid progress, high mortality, and high disability rate. Due to the complexity of the brainstem’s anatomical structure and functional importance, it is generally recognized that brainstem treatment is difficult and risky, so it has been regarded as a restricted area of surgery. However, in recent years, continuous progress is being made in many areas, including microsurgical ...
    Clinical diagnostic and therapeutic guidelines of stroke neurorestoration (2020 China version)
    Xiaoling Guo,Qun Xue,Jianhua Zhao,Yi Yang,Yang Yu,Dezhong Liu,Jing Liu,Wenwu Yang,Linsen Mu,Ping Zhang,Tianyi Wang,Hongyan Han,Shoufeng Liu,Yuhua Zhu,Tao Wang,Chuanqiang Qu
    2020, 8(4):  241-251.  doi:10.26599/JNR.2020.9040026
    Abstract ( 209 )   HTML ( 14)   PDF (450KB) ( 222 )  
    Stroke is the main cause of death and disability among Chinese, and neurorestoration is an effective therapeutic strategy for patients with stroke. In recent years, many achievements have been made in stroke neurorestoration, but viewpoints for managing stroke vary per discipline. In order to promote standardization of diagnosis and treatment for stroke neurorestoration, the Chinese Association of Neurorestoratology (CANR; Preparatory) and China Committee of International Association of Neurores...
    The progress of biomaterials in peripheral nerve repair and regeneration
    Yimeng Wang,Yuan Zhang,Xuemin Li,Qiqing Zhang
    2020, 8(4):  252-269.  doi:10.26599/JNR.2020.9040022
    Abstract ( 361 )   HTML ( 16)   PDF (700KB) ( 439 )  
    Repair and regeneration of the injured peripheral nerve (PN) is a challenging issue in clinics. Although the regeneration outcome of large PN defects is currently unsatisfactory, recently, the study of PN repair has considerably progressed. In particular, biomaterials for repairing PNs, such as nerve guidance conduits and nerve repair membranes, have been well developed. Herein, we summarize the anatomy of the PN, the pathophysiological features of the nerve injury, and the repair process post i...
    A meta-analysis on the efficiency of the time window of hyperbaric oxygen treatment on disorders of consciousness in China
    Yi Yang,Long Xu,Rong Xie,Yuanyuan Dang,Xiaoyu Xia,Jianghong He,Jizong Zhao
    2020, 8(4):  270-280.  doi:10.26599/JNR.2020.9040025
    Abstract ( 110 )   HTML ( 2)   PDF (691KB) ( 171 )  
    ObjectiveTo investigate the clinical effects of time window on hyperbaric oxygen treatment (HBOT) in patients with disorders of consciousness (DOC).MethodsAll the clinical research literature regarding HBOT for DOC published between January 2000 and November 2020 were retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Standards Database (WFSD) and VIP Database using Chinese key words disorders of consciousness, the vegetable state, minimally conscious state, or hyperbaric oxy...
    Human cytomegalovirus infection in brain tissue: Possible risk factor for cognitive status in Rasmussen's encephalitis
    Yao Zhang,Yuguang Guan,Xiongfei Wang,Mengyang Wang,Chongyang Tang,Tianfu Li,Guoming Luan
    2020, 8(4):  281-291.  doi:10.26599/JNR.2020.9040007
    Abstract ( 104 )   HTML ( 3)   PDF (1725KB) ( 59 )  
    Objective:Our purpose was to investigate the cytomegalovirus expression in patients with Rasmussen's encephalitis (RE) and to analyze the correlation between cytomegalovirus expression and the alteration of cognition.Methods:The expression of human cytomegalovirus (HCMV) in resected brain tissue from 36 children with RE was analyzed and the impact of cytomegalovirus infection on the cognitive function of patients was evaluated. The primary outcome was change in score from baseline to month 24 on...