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    Volume 9 No. 2
    05 June 2021
    Special Issue on Cell Therapy
    Gustavo Moviglia
    2021, 9(2):  81-82.  doi:10.26599/JNR.2021.9040018
    Abstract ( 64 )   HTML ( 4)   PDF (607KB) ( 128 )  
    Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke
    Jin Wang,Jianhua Zhao,Shaomin Li
    2021, 9(2):  83-93.  doi:10.26599/JNR.2021.9040012
    Abstract ( 40 )   HTML ( 3)   PDF (1268KB) ( 105 )  
    Olfactory ensheathing cells (OECs) are a special type of glial cell in the olfactory system, which exhibit neuroprotective, immunomodulatory, and angiogenic effects. Although many studies have focused on the reversal of demyelination and axonal degeneration (during spinal cord injury) by OECs, few reports have focused on the ability of OECs to repair ischemic nerve injury. This article reviews the protective effects of OEC transplantation in ischemic stroke and provides a theoretical basis and n...
    Olfactory ensheathing cell transplantation for chronic spinal cord injury: A long-term follow-up study
    Naifeng Kuang,Xiaoyu Wang,Yuexia Chen,Guifeng Liu,Fan’e Kong,Nan Wang,Rui Feng,Yan Wang,Xiaojing Du,Zuncheng Zheng
    2021, 9(2):  94-105.  doi:10.26599/JNR.2021.9040008
    Abstract ( 41 )   HTML ( 4)   PDF (984KB) ( 95 )  
    Spinal cord injury is a serious disabling condition. Transplantation of olfactory ensheathing cells (OECs) is one of the most promising treatments for spinal cord injury (SCI). Thirty-nine patients with chronic SCI received OEC transplantation and completed long-term follow-up, with a minimum follow-up of 7 years. We assessed sensorimotor function with the American Spinal Injury Association (ASIA) Impairment Scale (AIS) and autonomic nervous function by the International Standards to document re...
    Ten years of clinical observation of olfactory ensheathing cell transplantation in patients with spinal cord injury
    Zhijian Cheng,Rui Wang,Kai Cao,Guoyu Wang,Jie Qin,Haopeng Li,Jiaxi Li,Dong Wang,Xijing He
    2021, 9(2):  106-116.  doi:10.26599/JNR.2021.9040009
    Abstract ( 35 )   HTML ( 0)   PDF (2080KB) ( 89 )  
    Objective:To evaluate the long-term curative efficacy and safety of olfactory ensheathing cell (OEC) transplantation by 10 years of follow-up investigation.Methods:A follow-up observation was done on 13 patients with allograft olfactory bulb-derived OEC transplantation from September 2005 to September 2007 at the Second Affiliated Hospital of Xi’an Jiaotong University. After cell purification, amplification, and identification, a 2 × 107/mL cell suspension was prepared for transplantation. In th...
    Improved survival in amyotrophic lateral sclerosis patients following autologous bone marrow mononuclear cell therapy: a long term 10-year retrospective study
    Alok Sharma,Hemangi Sane,Amruta Paranjape,Ritu Varghese,Vivek Nair,Hema Biju,Dhanashree Sawant,Nandini Gokulchandran,Prerna Badhe
    2021, 9(2):  117-136.  doi:10.26599/JNR.2021.9040010
    Abstract ( 44 )   HTML ( 0)   PDF (2107KB) ( 80 )  
    Background:Promising results from previous studies using cell therapy have paved the way for an innovative treatment option for amyotrophic lateral sclerosis (ALS). There is considerable evidence of immune and inflammatory abnormalities in ALS. Bone marrow mononuclear cells (BMMNCs) possess immunomodulatory properties and could contribute to slowing of disease progression.Objective:Aim of our study was to evaluate the long-term effect of autologous BMMNCs combined with standard treatment on surv...
    A pilot study of clinical cell therapy for patients with vascular dementia
    Yunliang Wang, Xiaoling Guo, Yanqiu Liu, Yan Li, Ying Liu, Di Chen, Juan Xiao, Wenyong Gao, Yajun Liu, Bo Zhou, Ran Liu, Fei Liu, Weidong Chen, Deqiang Guo, Gensheng Mao, Hongyun Huang
    2021, 9(2):  137-150.  doi:10.26599/JNR.2021.9040011
    Abstract ( 46 )   HTML ( 1)   PDF (1661KB) ( 87 )  
    Background:Vascular dementia (VD) is a series of clinical and neurophysiological manifestations caused by cerebrovascular disease. As the human lifespan increases, the number of people affected by age-related dementia is growing at an alarming pace, but no proved therapeutic methods can stop it from getting worse.Objective:To investigate the neurorestorative effects of injecting olfactory ensheathing cells (OECs), Schwann cells (SCs), and olfactory receptor neurons (ORNs) into olfactory sub-muco...
    The inorganic chemicals that surround us: role of tellurium, selenium and zinc on behavioural functions in mammals
    Edgardo O. Alvarez,Osvaldo J. Sacchi,Silvia G. Ratti
    2021, 9(2):  151-163.  doi:10.26599/JNR.2021.9040015
    Abstract ( 27 )   HTML ( 0)   PDF (2088KB) ( 77 )  
    Living organisms live in continuous interaction with its environment. During this process changes in one can induce adaptive responses on the other. Many factors in the environment have been studied with the notorious distinction of been rare or to be of high intensity strength in its interaction with living organisms. However, little attention has been put on some factors that have constant interaction with organisms but usually have low intensity strength, such as the case of the inorganic che...